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The Cytogenetic Constitution of Embryos Resulting From Immature Oocytes (M1)

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ClinicalTrials.gov Identifier: NCT00544531
Recruitment Status : Completed
First Posted : October 16, 2007
Last Update Posted : October 16, 2007
Sponsor:
Information provided by:

Study Description
Brief Summary:

To examine the chromosomal number content in the blastomeres of embryos achieved from fertilization of immature oocytes at MI stage recruited following COH for IVF.

comparison of the genetic number content of embryos and their quality in terms of cleavage rate and morphological score reached after fertilization of immature oocytes at MI stage whether arrested at the MI stage or extruded the polar body, after in vitro maturation for a variable length of time.


Condition or disease
Infertility

Detailed Description:
Patients undergoing routine IVF, following informed consent, donated some of their unusable, immature- MI stage oocytes for our research. Following in vitro maturation for up to 2, 4, 8 and 24 hours after harvest, all immature oocytes in these 4 study groups underwent intracytoplasmic donor sperm injection (ICSI), whether they extruded their polar body (MI-PB or rescued MI) or not (arrested MI). Oocyte fertilization rate after 24 hours and embryonic development in terms of cleavage rate and morphology were assessed, for another 48 hours. Then the whole embryo was prepared for molecular cytogenetic evaluation using FISH (Fluorescence in situ hybridization) analysis of chromosomes x, y and 18.

Study Design

Study Type : Observational
Actual Enrollment : 23907 participants
Time Perspective: Prospective
Study Start Date : October 2005
Study Completion Date : March 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Infertility
U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Patients with presence of immature oocytes after ART stimulation

Exclusion Criteria:

  • Patients with less than total 7 oocytes
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00544531


Locations
Israel
Infertility unit,Assaf-Harofeh Medical Center
Zrifin, Israel, 70300
Sponsors and Collaborators
Assaf-Harofeh Medical Center
Investigators
Principal Investigator: Raphael Ron-el, professor Assaf-Harofeh Medical Center
More Information

ClinicalTrials.gov Identifier: NCT00544531     History of Changes
Other Study ID Numbers: 76/05
First Posted: October 16, 2007    Key Record Dates
Last Update Posted: October 16, 2007
Last Verified: September 2005

Keywords provided by Assaf-Harofeh Medical Center:
MI oocytes, FISH,chromosomal aberrations

Additional relevant MeSH terms:
Infertility
Genital Diseases, Male
Genital Diseases, Female