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Biochemical Marker to Predict the Recurrence of Atrial Fibrillation After Surgical Maze Procedure

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ClinicalTrials.gov Identifier: NCT00542659
Recruitment Status : Completed
First Posted : October 11, 2007
Last Update Posted : July 25, 2011
Sponsor:
Information provided by:
Samsung Medical Center

Brief Summary:

The role of plasma NT-proBNP, hsCRP, TIMP-1(Tissue inhibitors of MetalloProteinase-1),TGF-b, MMP-3(Matrix MetalloProteinase-3), and pro-MMP-1 in predicting the recurrence of AF after surgical Maze procedure.

The association of expression of CTGF, TGF-b, BNP, ANP, collagen-1, and collagen-3 in LA with the recurrence of AF after surgical Maze procedure.


Condition or disease
Atrial Fibrillation

Study Type : Observational
Estimated Enrollment : 86 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Plasma ANP and NT-pro-BNP, Atrial Anatomical Change May Determine the Outcome of Maze Operation
Study Start Date : February 2005
Actual Primary Completion Date : December 2007
Actual Study Completion Date : February 2008

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Primary Outcome Measures :
  1. AF recurrence [ Time Frame: year ]

Biospecimen Retention:   Samples Without DNA
plasma mRNA


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Ages Eligible for Study:   30 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The patients who have valvular heart disease with atrial fibrillation and are scheduled for operation
Criteria

Inclusion Criteria:

  • The patients who have valvular heart disease with atrial fibrillation and are scheduled for operation

Exclusion Criteria:

  • Coronary heart disease
  • Congestive heart failure

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00542659


Locations
Korea, Republic of
Samsung Medical Center
Seoul, Korea, Republic of, 135-710
Sponsors and Collaborators
Samsung Medical Center
Investigators
Principal Investigator: Young Keun On, MD Samsung Medical Center

Responsible Party: Young Keun On, MD, Samsung Medical Center
ClinicalTrials.gov Identifier: NCT00542659     History of Changes
Other Study ID Numbers: 2005-02-019
First Posted: October 11, 2007    Key Record Dates
Last Update Posted: July 25, 2011
Last Verified: July 2011

Keywords provided by Samsung Medical Center:
Atrial fibrillation
Maze procedure

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes