Comparison of the Gastric Acid Suppressive Effects of Esomeprazole and Generic Omeprazole
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Proton pump inhibitors (PPI) are used to decrease stomach acid secretion. A generic form of omeprazole, one of the PPIs, is on the market. With cheaper than brand name PPIs, it is unclear whether generic omeprazole is as effective clinically. This study compares generic omeprazole with half-dose esomeprazole, the strongest brand name PPI. The half-dose esomeprazole is in fact cheaper than generic omeprazole. Healthy volunteers will take each medication in turn for 7 days and their stomach acid will be measured while taking each medication. We hypothesize that half-dose esomeprazole is better at suppressing stomach acid than generic omeprazole.
Condition or disease
Drug: Esomeprazole firstDrug: Generic omeprazole first
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
healthy, non-smoking volunteers older than 18 years of age
history of gastrointestinal disease
previous eradication of Helicobacter pylori
any prescription or over the counter antacid medication