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Pilot Investigation of a Multinutrient Supplement on Skin Aging and Aging Metabolites in Healthy Women

This study has been completed.
Nu Skin Enterprises
Information provided by (Responsible Party):
Alfred Lane, Stanford University Identifier:
First received: October 5, 2007
Last updated: December 12, 2012
Last verified: December 2012
We are seeking healthy female volunteers to determine if multinutrient supplementation affects visible signs of skin aging as well as blood measurements of aging. We are seeking smokers and non-smokers.

Condition Intervention
Skin Diseases
Drug: Dietary Supplement: LifePak Nano

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Pilot Investigation of a Multinutrient Supplement on Skin Aging and Aging Metabolites in Healthy Women

Resource links provided by NLM:

Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Determine whether supplementation affects skin aging [ Time Frame: Three months ]
    Assessment of metabolome and facial photographs

Secondary Outcome Measures:
  • Determine if supplementation affects blood markers of aging [ Time Frame: Three months ]
    Metabolomic analysis, arNOX analysis

Enrollment: 71
Study Start Date: October 2007
Study Completion Date: January 2012
Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Drug: Dietary Supplement: LifePak Nano
Daily use
Other Name: Life Pak Nano
Smoker arm
Drug: Dietary Supplement: LifePak Nano
Daily use
Other Name: Life Pak Nano


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:- Fitzpatrick Skin type I or II

  • Nonpregnant Females, age 18-30 or 50-70
  • Body Mass Index Normal or Overweight
  • If age 18-30, must be non-smoker
  • Willing to fast for 8 hours prior to a blood draw
 Exclusion Criteria:- History of cosmetic surgery
  • Use of anti-aging medications within 3 months of enrollment
  • Use of over-the-counter anti-aging creams (not sunscreens) more than once per week within one month of enrollment
  • Use of dietary supplements including vitamins within one month of enrollment
  • Use of tanning beds or excessive UV exposure (greater than 2 hours per day) within one month of enrollment
  • Use of sunless tanners within one month of enrollment
  • Uncontrolled or ongoing serious medical condition
  • Participation in another clinical study involving use of an investigational drug or product
  • Medical condition which, at the discretion of the investigator, will have a significant impact on ability to judge participant's skin characteristics, including age.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00541931

United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305
Sponsors and Collaborators
Stanford University
Nu Skin Enterprises
Principal Investigator: Dr. Anne Lynn S. Chang Stanford University
  More Information

Responsible Party: Alfred Lane, Professor, Stanford University Identifier: NCT00541931     History of Changes
Other Study ID Numbers: 10622
Study First Received: October 5, 2007
Last Updated: December 12, 2012

Additional relevant MeSH terms:
Skin Diseases processed this record on April 27, 2017