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Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine

This study has been completed.
Information provided by:
Danish Headache Center Identifier:
First received: October 9, 2007
Last updated: May 28, 2008
Last verified: May 2008
The aim of the present study is to explore the importance of migraine genes on the headache/migraine responses after GTN in FHM-patients and healthy volunteers.

Condition Intervention
Familial Hemiplegic Migraine
Drug: Nitroglycerine

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine

Resource links provided by NLM:

Further study details as provided by Danish Headache Center:

Primary Outcome Measures:
  • Migraine and associated symptoms [ Time Frame: 0-14 h ]
  • Migraine aura [ Time Frame: 0 - 14 h ]

Enrollment: 30
Study Start Date: October 2007
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Patients
Drug: Nitroglycerine
Nitroglycerine infusion over 20 minutes: 0.5 ug/kg/min
Active Comparator: Controls
Drug: Nitroglycerine
Nitroglycerine infusion over 20 minutes: 0.5 ug/kg/min

Detailed Description:

Glyceryl trinitrate (GTN) induces migraine attacks indistinguishable from spontaneous attacks in approximately 80% of migraine sufferers. After systemic administration GTN is transformed to nitric oxide (NO). Treatment of spontaneous migraine attacks with an inhibitor of NO is effective in 60% of patients. These data show that NO is involved in both initiation and maintenance of migraine attack.

The importance of migraine genes is disputed. Evidence from FHM patients with known mutations indicates that migraine pathways in FHM may be different from normal migraine. The aim of the present study is to examine whether this difference also exists in FHM patients without known mutations. The project will improve our understanding of the neurobiology of migraine and stimulate development of new treatment targets.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Diagnosis of familial hemiplegic migraine (IHS-classification criteria)

Exclusion Criteria:

Patients and controls:

  • A history of cerebrovascular disease and other CNS- disease
  • A history of serious somatic and mental disease
  • A history suggesting ischaemic heart disease
  • A history of hypo- or hypertension
  • Daily intake of medication apart from oral contraceptives
  • Abuse of alcohol or medicine (opioid analgesics).
  • Pregnant or breastfeeding women.

On the study day:

  • No intake of a simple analgesic in the previous 48 hours
  • No headache in the previous 48 hours
  Contacts and Locations
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Please refer to this study by its identifier: NCT00541736

Danish Headache Center, University of Copenhagen, Faculty of Health Sciences, Department of Neurology, Glostrup Hospital
Glostrup, Copenhagen, Denmark, 2600
Sponsors and Collaborators
Danish Headache Center
Principal Investigator: Jakob Møller Hansen, MD Danish Headache Center
  More Information Identifier: NCT00541736     History of Changes
Other Study ID Numbers: FHM-GTN-2007-08
Study First Received: October 9, 2007
Last Updated: May 28, 2008

Keywords provided by Danish Headache Center:
Familial Hemiplegic Migraine

Additional relevant MeSH terms:
Migraine Disorders
Migraine with Aura
Headache Disorders, Primary
Headache Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Vasodilator Agents processed this record on April 28, 2017