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Transient Osteoporosis of Pregnancy: A Possible Peptide Mediator

This study has suspended participant recruitment.
Information provided by:
Hadassah Medical Organization Identifier:
First received: October 7, 2007
Last updated: March 17, 2008
Last verified: March 2008

Transient osteoporosis of pregnancy (TOoP) is uncommonly encountered in orthopedic and obstetric practice, with most reports consisting of single cases.

This rare condition consists of significant osteoporosis affecting the hips and spine, causing significant morbidity, and putting young female patients at risk for vertebral and femoral neck fractures.

The pathogenesis of transient osteoporosis of pregnancy is unknown, with various theories as to its etiology.

Recently, a number of reports have described elevated levels of PTHrP in patients with transient osteoporosis in pregnancy and of the postpartum period Our goal in this study is to assess the role of PTHrP in transient osteoporosis of pregnancy

Transient Osteperosis

Study Type: Observational
Study Design: Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Hadassah Medical Organization:


Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female

Inclusion Criteria:

  • Signed Informed consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00541645

Sponsors and Collaborators
Hadassah Medical Organization
Principal Investigator: Efrain Liebner, MD Hadassah Medical Organization
Study Chair: Meir Liebergall, M.D Hadassah Medical Organization
Study Director: Tzvi Bar-Shavit, Ph.D The Hebrew University
  More Information Identifier: NCT00541645     History of Changes
Other Study ID Numbers: Lib001-HMO-CTIL
Study First Received: October 7, 2007
Last Updated: March 17, 2008 processed this record on September 21, 2017