Ephedrine for the Treatment of Congenital Myasthenia
|ClinicalTrials.gov Identifier: NCT00541216|
Recruitment Status : Unknown
Verified October 2007 by Hadassah Medical Organization.
Recruitment status was: Enrolling by invitation
First Posted : October 10, 2007
Last Update Posted : October 10, 2007
Previous research has demonstrated possible efficacy of Ephedrine in the treatment of congenital myasthenia caused by end-plate acetylcholinesterase deficiency.
The aim of the current study is to test the hypothesis that Ephedrine may be beneficial to these patients.
To test this hypothesis we will perform a double blind, placebo-controlled, crossover study clinical efficacy and safety study.
Drug naïve patients who agree to participate will be randomized to two groups. Each group will be treated in a blinded manner for 5 weeks with either placebo or Ephedrine HCl in an escalating dose up to 100 mg per day divided in two doses. After five weeks the groups will cross over and continue treatment or placebo for a further five weeks.
Evaluations of strength and fatiguability will be done at baseline, at the end of each five week period and after a further two weeks.
Safety will be assessed weekly by the investigators using interview and physical examination.
Outcome measures will include Barthel index, Quality of life questionnaire, Timed up and go, spirometry, timed elevation of limbs, and force measurements.
All patients will report to the clinic as per study schedule (See Appendix A). Specifically, the 12 clinic visits will include: baseline (1), safety and efficacy assessments(10) and closeout (1).
|Condition or disease||Intervention/treatment||Phase|
|Myasthenic Syndromes, Congenital||Drug: Ephedrine||Phase 1 Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||15 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Study Start Date :||October 2007|
- strength and fatiguability: walking, straight arm raising, spirometry. [ Time Frame: 5 weeks ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00541216
|Hadassah Medical Organization, Jerusalem, Israel|
|Principal Investigator:||Simon Edvardson||Hadassah Medical Organization|