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Optical Biopsy of Human Skin in Conjunction With Laser Treatment

This study has been completed.
Beckman Laser Institute University of California Irvine
Information provided by (Responsible Party):
Beckman Laser Institute and Medical Center, University of California, Irvine Identifier:
First received: October 4, 2007
Last updated: February 8, 2017
Last verified: February 2017
This study is to compare the ability of optical biopsy. Research can use light enters the skin, collected, analyzed by the computer, and a picture created for the pathologist to conventional histologic examination compare with the pathologist looking at the piece of tissue through a microscope makes the diagnosis.

Condition Intervention
Malignant Melanoma
Merkel Cell Carcinoma
Basal Cell Carcinoma
Squamous Cell Carcinoma
Atypical Nevi
Congenital Nevi
Seborrheic Keratosis
Paget's Disease
Kaposi's Sarcoma
Port Wine Stain
Device: Optical Biopsy imaging

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Optical Biopsy of Human Skin in Conjunction With Laser Treatment

Resource links provided by NLM:

Further study details as provided by Beckman Laser Institute and Medical Center, University of California, Irvine:

Primary Outcome Measures:
  • normal skin [ Time Frame: 12 weeks ]

Enrollment: 113
Study Start Date: June 1999
Study Completion Date: July 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Optical Biopsy
Optical Biopsy imaging
Device: Optical Biopsy imaging
Optical Biopsy imaging

Detailed Description:
The Optical measurements provide quantitative optical property values that reflect changes in tissue perfusion, oxygen consumption, and cell/matrix development. Each measurement requires less than 5 minutes to execute. The measurements will be taken before and after skin treatment.This non-invasive, non-contact technique has great potential as a means to diagnose different skin problems without the need to obtain a piece of tissue from the skin.

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
primary care clinic, community sample

Inclusion Criteria:

  • Male or female age > 18 years

Exclusion Criteria:

  • current participation in any other investigational drug evaluation
  • inability to understand and carry out instructions
  Contacts and Locations
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Please refer to this study by its identifier: NCT00540566

United States, California
Beckman Laser Institute, Unversity of California Irvine
Irvine, California, United States, 92612
Sponsors and Collaborators
University of California, Irvine
Beckman Laser Institute University of California Irvine
Principal Investigator: John S Nelson, M.D,Ph.D Beckman Laser Institue, University of California Irvine
  More Information

Responsible Party: Beckman Laser Institute and Medical Center, J.S.Nelson, MD,PhD,Professor of Surgery and Biomedical Engineering, University of California, Irvine Identifier: NCT00540566     History of Changes
Other Study ID Numbers: NIH-LAMPP-1996-200
Study First Received: October 4, 2007
Last Updated: February 8, 2017

Additional relevant MeSH terms:
Carcinoma, Squamous Cell
Carcinoma, Basal Cell
Sarcoma, Kaposi
Keratosis, Seborrheic
Carcinoma, Merkel Cell
Port-Wine Stain
Hemangioma, Capillary
Histiocytoma, Benign Fibrous
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms, Squamous Cell
Skin Diseases
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms, Nerve Tissue
Nevi and Melanomas
Neoplasms, Basal Cell
Herpesviridae Infections
DNA Virus Infections
Virus Diseases
Neoplasms, Connective and Soft Tissue
Neoplasms, Vascular Tissue processed this record on May 25, 2017