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Bone Density in Patients With Schizophrenia

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ClinicalTrials.gov Identifier: NCT00540267
Recruitment Status : Completed
First Posted : October 5, 2007
Last Update Posted : November 4, 2008
Sponsor:
Information provided by:
Inje University

Brief Summary:

People with chronic mental disorder such as schizophrenia and alcohol abuse are high risk groups for developing osteoporosis.

To evaluate the prevalence of bone mineral density in men patients with schizophrenia with alcohol abuse, the investigators will compare bone mineral density between patient with schizophrenia with and without alcohol abuse.


Condition or disease Intervention/treatment
Schizophrenia Alcohol Abuse Other: No Intervention

Detailed Description:
People with schizophrenia has been known as a high risk groups for developing osteoporosis, because of lack of exercise, poor nutrition and high rate of smoking. Those with alcohol abuse may be higher risk group than one with schizophrenia without alcohol abuse, because they frequently have several medical problems such as liver dysfunction, Vitamin D deficiency, hyperparathyroidism and those medical condition increase risk for developing osteoporosis. Also alcohol itself can increase bone loss too by disturbing bone remodeling and enhancing bone fragility. To compare the prevalence of bone mineral density in patients with schizophrenia with alcohol abuse to those without alcohol problem, we will investigate BMD in large population of Korean patients with those illnesses.

Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Case Control
Official Title: Bone Mineral Density in the Korean Patients With Chronic Schizophrenia With Alcohol Abuse
Study Start Date : November 2007
Actual Primary Completion Date : November 2008
Actual Study Completion Date : November 2008

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Group/Cohort Intervention/treatment
Schizophrenia
Chronic schizophrenia with aged 18-80 years
Other: No Intervention
No Intervention



Primary Outcome Measures :
  1. The change of bone mineral density [ Time Frame: cross sectional and prospective ]

Secondary Outcome Measures :
  1. The effects of Smoking and antipsychotic drug on BMD [ Time Frame: Cross sectional Study ]


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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
people with schizophrenia, gaed between 18-80 years, with no endocrine disorder
Criteria

Inclusion Criteria:

  • DSM-IV diagnosis of schizophrenia
  • Onset of illness more than 5 years.

Exclusion Criteria:

  • No severe Medical and endocrinological disorder

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00540267


Locations
Korea, Republic of
Joo-Cheol Shim
Busan, Korea, Republic of, 614-735
Sponsors and Collaborators
Inje University
Investigators
Study Director: Joo-Cheol Shim, MD,PhD Inje University

Responsible Party: Joo Shim, Imje University Busan Paik Hospital
ClinicalTrials.gov Identifier: NCT00540267     History of Changes
Other Study ID Numbers: BMD07
Korea Health 21 R&D Project
First Posted: October 5, 2007    Key Record Dates
Last Update Posted: November 4, 2008
Last Verified: October 2008

Keywords provided by Inje University:
Schizophrenia
Alcohol Abuse
Bone Density

Additional relevant MeSH terms:
Schizophrenia
Alcoholism
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders