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Bone Density in Patients With Schizophrenia

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: October 5, 2007
Last Update Posted: November 4, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Inje University

People with chronic mental disorder such as schizophrenia and alcohol abuse are high risk groups for developing osteoporosis.

To evaluate the prevalence of bone mineral density in men patients with schizophrenia with alcohol abuse, the investigators will compare bone mineral density between patient with schizophrenia with and without alcohol abuse.

Condition Intervention
Schizophrenia Alcohol Abuse Other: No Intervention

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Bone Mineral Density in the Korean Patients With Chronic Schizophrenia With Alcohol Abuse

Resource links provided by NLM:

Further study details as provided by Inje University:

Primary Outcome Measures:
  • The change of bone mineral density [ Time Frame: cross sectional and prospective ]

Secondary Outcome Measures:
  • The effects of Smoking and antipsychotic drug on BMD [ Time Frame: Cross sectional Study ]

Estimated Enrollment: 300
Study Start Date: November 2007
Study Completion Date: November 2008
Primary Completion Date: November 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Chronic schizophrenia with aged 18-80 years
Other: No Intervention
No Intervention

Detailed Description:
People with schizophrenia has been known as a high risk groups for developing osteoporosis, because of lack of exercise, poor nutrition and high rate of smoking. Those with alcohol abuse may be higher risk group than one with schizophrenia without alcohol abuse, because they frequently have several medical problems such as liver dysfunction, Vitamin D deficiency, hyperparathyroidism and those medical condition increase risk for developing osteoporosis. Also alcohol itself can increase bone loss too by disturbing bone remodeling and enhancing bone fragility. To compare the prevalence of bone mineral density in patients with schizophrenia with alcohol abuse to those without alcohol problem, we will investigate BMD in large population of Korean patients with those illnesses.

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
people with schizophrenia, gaed between 18-80 years, with no endocrine disorder

Inclusion Criteria:

  • DSM-IV diagnosis of schizophrenia
  • Onset of illness more than 5 years.

Exclusion Criteria:

  • No severe Medical and endocrinological disorder
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00540267

Korea, Republic of
Joo-Cheol Shim
Busan, Korea, Republic of, 614-735
Sponsors and Collaborators
Inje University
Study Director: Joo-Cheol Shim, MD,PhD Inje University
  More Information

Responsible Party: Joo Shim, Imje University Busan Paik Hospital
ClinicalTrials.gov Identifier: NCT00540267     History of Changes
Other Study ID Numbers: BMD07
Korea Health 21 R&D Project
First Submitted: October 4, 2007
First Posted: October 5, 2007
Last Update Posted: November 4, 2008
Last Verified: October 2008

Keywords provided by Inje University:
Alcohol Abuse
Bone Density

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders