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GLP-2 (Glucagonlike Peptide-2) and Blood Flow

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00540215
First Posted: October 5, 2007
Last Update Posted: February 11, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Glostrup University Hospital, Copenhagen
  Purpose

It is the study aim to investigate the effect of glp-2 on blood flow in humans. we wish to study eventual changes in renal blood flow, carotic blood flow and cardiac out put.

GLP-2 will be administered subcutaneously, and the effect monitored by doppler ultra sound scannings and cotinuesly measuring of cardiac out put and blood pressure.

The study will include 15 healhty volunteers, 10 wil receive 450 nmol GLP-2 and 5 will receive 1 ml of isotonic saline (as baseline reference).


Condition Intervention
Regional Blood Flow Other: Glucagonlike peptide

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: The Role of GLP-2 in Univercal Changes in Blood Flow in Humans

Further study details as provided by Glostrup University Hospital, Copenhagen:

Primary Outcome Measures:
  • effect of glp-2 [ Time Frame: during study ]

Secondary Outcome Measures:
  • potential new ideas for further studies [ Time Frame: months to years ]

Enrollment: 15
Study Start Date: October 2007
Study Completion Date: February 2008
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
450 nmol GLP-2 SC
Other: Glucagonlike peptide
450 nmol native form, synthetic
Placebo Comparator: 2
1 ml isotonic saline SC
Other: Glucagonlike peptide
450 nmol native form, synthetic

Detailed Description:
se the above
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age 20-60
  • Healthy
  • No medication
  • Not pregnant

Exclusion Criteria:

  • All of the persons not meeting the abowe mentioned criteria
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00540215


Locations
Denmark
Glostrup University Hospital
Glostrup, Region Hovedstaden, Denmark, 2600
Sponsors and Collaborators
Glostrup University Hospital, Copenhagen
Investigators
Principal Investigator: lasse bremholm, MD Glostrup university hospital
  More Information

ClinicalTrials.gov Identifier: NCT00540215     History of Changes
Other Study ID Numbers: H-D-2007-0050
First Submitted: October 4, 2007
First Posted: October 5, 2007
Last Update Posted: February 11, 2011
Last Verified: October 2007