Effects of Chocolate in Patients With Chronic Heart Failure
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|ClinicalTrials.gov Identifier: NCT00538941|
Recruitment Status : Completed
First Posted : October 3, 2007
Last Update Posted : October 28, 2009
The aim of the present study is to investigate whether in patients with chronic heart failure endothelial dysfunction and baroreceptor function is altered by ingestion of a flavonoid-rich dark chocolate in comparison to placebo chocolate (Nestlé Placebo Chocolate) on top of standard medication.
Moreover, we will evaluate the effect of chocolate on oxidative stress, platelet adhesion as well as systemic inflammatory response such as C-reactive protein and pro-inflammatory cytokines in patients with chronic heart failure.
|Condition or disease||Intervention/treatment||Phase|
|Heart Failure||Dietary Supplement: Nestlé Noir intense 40 grx2 Dietary Supplement: Nestlé Placebo Chocolate 40 grx2||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||22 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Effects of Swiss Dark Chocolate on Endothelial and Baroreceptor Function and Markers of Inflammation in Patients With Chronic Heart Failure|
|Study Start Date :||November 2005|
|Actual Primary Completion Date :||October 2009|
|Actual Study Completion Date :||October 2009|
Active Comparator: 1
daily intake of 40gr chocolate (Nestlé Noir intense) in the morning and 40gr chocolate in the evening.
Dietary Supplement: Nestlé Noir intense 40 grx2
daily intake of 40gr chocolate (Nestlé Noir intense or Nestlé Placebo Chocolate) in the morning and 40gr chocolate in the evening.
Placebo Comparator: 2
Nestlé Placebo Chocolate 40gr in the morning and 40gr chocolate in the evening.
Dietary Supplement: Nestlé Placebo Chocolate 40 grx2
Nestlé Placebo Chocolate 40 gr in the morning and 40gr chocolate in the evening.
- endothelial function [ Time Frame: acute (2 hours), chronic (2 and 4 weeks) ]
- shear-stress dependent platelet function; Oxidative stress; baroreceptor function Systemic inflammatory response (assessed as change in high sensitivity CRP, 8-Isoprostanes, CD-40 ligand); Plasma epicatechins. [ Time Frame: acute (2 hours), chronic (2 and 4 weeks) ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00538941
|Cardiovascular Center, Cardiology, University Hospital of Zurich|
|Zurich, Switzerland, 8091|
|Principal Investigator:||Georg Noll, MD||Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland|