Effects of Chocolate in Patients With Chronic Heart Failure
The aim of the present study is to investigate whether in patients with chronic heart failure endothelial dysfunction and baroreceptor function is altered by ingestion of a flavonoid-rich dark chocolate in comparison to placebo chocolate (Nestlé Placebo Chocolate) on top of standard medication.
Moreover, we will evaluate the effect of chocolate on oxidative stress, platelet adhesion as well as systemic inflammatory response such as C-reactive protein and pro-inflammatory cytokines in patients with chronic heart failure.
|Heart Failure||Dietary Supplement: Nestlé Noir intense 40 grx2 Dietary Supplement: Nestlé Placebo Chocolate 40 grx2|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:||Effects of Swiss Dark Chocolate on Endothelial and Baroreceptor Function and Markers of Inflammation in Patients With Chronic Heart Failure|
- endothelial function [ Time Frame: acute (2 hours), chronic (2 and 4 weeks) ]
- shear-stress dependent platelet function; Oxidative stress; baroreceptor function Systemic inflammatory response (assessed as change in high sensitivity CRP, 8-Isoprostanes, CD-40 ligand); Plasma epicatechins. [ Time Frame: acute (2 hours), chronic (2 and 4 weeks) ]
|Study Start Date:||November 2005|
|Study Completion Date:||October 2009|
|Primary Completion Date:||October 2009 (Final data collection date for primary outcome measure)|
Active Comparator: 1
daily intake of 40gr chocolate (Nestlé Noir intense) in the morning and 40gr chocolate in the evening.
Dietary Supplement: Nestlé Noir intense 40 grx2
daily intake of 40gr chocolate (Nestlé Noir intense or Nestlé Placebo Chocolate) in the morning and 40gr chocolate in the evening.
Placebo Comparator: 2
Nestlé Placebo Chocolate 40gr in the morning and 40gr chocolate in the evening.
Dietary Supplement: Nestlé Placebo Chocolate 40 grx2
Nestlé Placebo Chocolate 40 gr in the morning and 40gr chocolate in the evening.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00538941
|Cardiovascular Center, Cardiology, University Hospital of Zurich|
|Zurich, Switzerland, 8091|
|Principal Investigator:||Georg Noll, MD||Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland|