Effect of Mental Stress on Platelet Function
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ClinicalTrials.gov Identifier: NCT00538707 |
Recruitment Status :
Completed
First Posted : October 3, 2007
Last Update Posted : February 10, 2010
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Mental Stress | Behavioral: 2-minute Bondet test | Not Applicable |
Psychological stress is an important cardiovascular risk factor. Activation of platelets plays an important role in atherosclerosis development and it could be one of the mechanisms linking psychological stress and cardiovascular diseases.
We plan to include 32 healthy subjects. (16 in every group). One group with subjects at age 20 - 49 and the other group with subjects at age 50 - 70 years.
The aim of the study will be to assess the acute and chronic effect of a standard short mental stress (2-minute Bondet Test) on platelet function and of the level of endothelin-1, catecholamines and cortisol. We plan to evaluate if age may play a role in the effect of psychological stress on platelet function.
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 32 participants |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | Effect of Mental Stress on Platelet Function in Healthy Subjects |
Study Start Date : | September 2007 |
Actual Primary Completion Date : | December 2009 |
Actual Study Completion Date : | December 2009 |
Arm | Intervention/treatment |
---|---|
Experimental: Young subjects |
Behavioral: 2-minute Bondet test
2-minute Bondet test
Other Name: 2-minute Bondet light test |
Experimental: Older subjects |
Behavioral: 2-minute Bondet test
2-minute Bondet test
Other Name: 2-minute Bondet light test |
- Evaluation of platelet function (shear stress dependent platelet adhesion and aggregation) before and after mental stress [ Time Frame: 60 minutes ]
- Evaluation of the plasma level of endothelin, catecholamines and salivary cortisol level before and after mental stress [ Time Frame: 60 minutes ]

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Ages Eligible for Study: | 20 Years to 70 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- healthy subjects between 20 - 70 years of age
- written informed consent
- no evidence of diseases
Exclusion Criteria:
- pregnancy
- oral contraceptives
- smoking
- use of aspirin or NSAIDs within the last week
- use of benzodiazepines within the last week
- Alcohol or drug abuse
- participation in another study within the last month

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00538707
Switzerland | |
University Hospital of Zurich | |
Zurich, Switzerland |
Principal Investigator: | Georg Noll, MD | University of Zurich |
Responsible Party: | University of Zurich, University Hospital Zurich |
ClinicalTrials.gov Identifier: | NCT00538707 |
Other Study ID Numbers: |
EK-1382 |
First Posted: | October 3, 2007 Key Record Dates |
Last Update Posted: | February 10, 2010 |
Last Verified: | February 2010 |
mental stress platelet adhesion platelet function catecholamines |
Stress, Psychological Behavioral Symptoms |