Whole Body Magnetic Resonance Angiography in Ischemic Patients
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|ClinicalTrials.gov Identifier: NCT00538408|
Recruitment Status : Unknown
Verified February 2009 by Copenhagen University Hospital at Herlev.
Recruitment status was: Recruiting
First Posted : October 2, 2007
Last Update Posted : February 3, 2009
|Condition or disease||Intervention/treatment|
|Atherosclerosis Intermittent Claudication||Procedure: Whole body magnetic resonance angiography (dotarem) Device: Whole body magnetic resonance angiography (vasovist)|
Atherosclerosis of the lower leg arteries is a common disease. Patients with this condition has symptoms of ischemia, for instance intermittent claudication (pain during exercise). Diagnosis of atherosclerosis in the legs is normally done with an interventional x-ray-based angiography (DSA- digital subtraction angiography). This is uncomfortable for the patient, and associated with risks of complications (bleeding, vascular damage, embolism).A novel approach to diagnosing atherosclerosis is the use of magnetic resonance angiography. A variant of this is the whole body magnetic resonance angiography(WB-MRA), that produce a picture of the arteries in almost the whole body (excluding the coronary arteries). WB-MRA has a number of advantages compared to DSA. It does not use ionizing radiation, is not invasive, uses a contrast medium with fewer side affects and finally gives a covers a great deal of the arteries in the body.
This study will compare WB-MRA with DSA in patients with symptoms of peripheral atherosclerosis in the lower legs. We will investigate 2 different contrast agents used for WB-MRA. The patients will be randomized to receive either the contrast medium Dotarem or the contrast medium Vasovist. In both groups we will compare the results of WB-MRA with DSA.
|Study Type :||Observational|
|Estimated Enrollment :||80 participants|
|Official Title:||Whole Body Magnetic Resonance Angiography in Patients With Symptomatic Peripheral Ischemia|
|Study Start Date :||September 2007|
|Estimated Study Completion Date :||January 2010|
- Vascular diagnostic quality on the WB-MRA. Degree of arterial stenosis on the WB-MRA.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00538408
|Contact: Yousef W. Nielsen, MD||+45 firstname.lastname@example.org|
|Contact: jakob M Møller, M.Sc.||+ +45 email@example.com|
|Department of Radiology, Herlev University Hospital||Recruiting|
|Herlev, Copenhagen, Denmark, DK-2730|
|Contact: Yousef W. Nielsen, MD. +45 4488 4391 firstname.lastname@example.org|
|Principal Investigator: Yousef W. Nielsen, MD|
|Study Chair:||Henrik S Thomsen, Prof.||University Hospital at Herlev Copenhagen Denmark|