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Language in Primary Progressive Aphasia

This study is currently recruiting participants.
Verified September 2017 by Marsel Mesulam, Northwestern University
Sponsor:
ClinicalTrials.gov Identifier:
NCT00537004
First Posted: September 28, 2007
Last Update Posted: September 13, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborator:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Information provided by (Responsible Party):
Marsel Mesulam, Northwestern University
  Purpose
The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.

Condition
Primary Progressive Aphasia

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Language in Primary Progressive Aphasia

Resource links provided by NLM:


Further study details as provided by Marsel Mesulam, Northwestern University:

Primary Outcome Measures:
  • Neuropsychological variables [ Time Frame: Immediately after testing and at two years post-testing ]

Estimated Enrollment: 300
Study Start Date: May 2007
Estimated Study Completion Date: April 2023
Estimated Primary Completion Date: April 2022 (Final data collection date for primary outcome measure)
Groups/Cohorts
PPA (Primary Progressive Aphasia)
Individuals with primary progressive aphasia
Control
Individuals with no diagnosis of any type of dementia

Detailed Description:

The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies.

During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), an MRI (a non-invasive brain-imaging procedure), an EEG (another non-invasive procedure that looks at brain waves when you think) and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures.

The study will recruit approximately 15 participants with PPA per year. For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Participants with PPA will be recruited from the Northwestern University Alzheimer's Disease Center Core registry, the Northwestern University Neurobehavior and Memory Clinic, and from those who contact the center that are interested in PPA research.
Criteria

Inclusion Criteria:

  • Diagnosis of primary progressive aphasia
  • Right-handed
  • English speaker
  • Visual acuity of 20/30 corrected
  • Adequate hearing to follow conversation
  • Safe for an MRI scan

Exclusion Criteria:

  • Left-handedness
  • Claustrophobia
  • Presence of significant medical illness that initially or in the future could interfere with continued participation in the study
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00537004


Contacts
Contact: Benjamin Rader 312-908-9681 benjamin.rader@northwestern.edu

Locations
United States, Illinois
Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Benjamin Rader    312-908-9681    benjamin.rader@northwestern.edu   
Principal Investigator: M.-Marsel Mesulam, MD         
Sponsors and Collaborators
Northwestern University
National Institute on Deafness and Other Communication Disorders (NIDCD)
Investigators
Principal Investigator: Marsel Mesulam, MD Northwestern University Feinberg School of Medicine
  More Information

Additional Information:
Publications:
Responsible Party: Marsel Mesulam, Director, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University
ClinicalTrials.gov Identifier: NCT00537004     History of Changes
Other Study ID Numbers: IA0125
R01DC008552 ( U.S. NIH Grant/Contract )
First Submitted: September 26, 2007
First Posted: September 28, 2007
Last Update Posted: September 13, 2017
Last Verified: September 2017

Keywords provided by Marsel Mesulam, Northwestern University:
primary progressive aphasia
frontotemporal dementia
semantic dementia
progressive nonfluent aphasia
progressive aphasia
frontotemporal lobar degeneration

Additional relevant MeSH terms:
Pick Disease of the Brain
Frontotemporal Dementia
Dementia
Frontotemporal Lobar Degeneration
Aphasia
Aphasia, Primary Progressive
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Brain Diseases
Central Nervous System Diseases
Neurocognitive Disorders
Mental Disorders
TDP-43 Proteinopathies
Neurodegenerative Diseases
Proteostasis Deficiencies
Metabolic Diseases