Language in Primary Progressive Aphasia

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ClinicalTrials.gov Identifier: NCT00537004

Recruitment Status : Recruiting

First Posted : September 28, 2007

Last Update Posted : January 25, 2023

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View this study on Beta.ClinicalTrials.gov

Sponsor:

Collaborator:

National Institute on Aging (NIA)

Information provided by (Responsible Party):

Marsel Mesulam, Northwestern University

Study Description

Brief Summary:

The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.

Condition or disease
Primary Progressive Aphasia

Detailed Description:

The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies.

During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), advanced imaging (MRI and PET), cognitive experiments, and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures.

For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study.

Study Design

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Study Type :	Observational
Estimated Enrollment :	500 participants
Observational Model:	Cohort
Time Perspective:	Prospective
Official Title:	Asymmetric Neurodegeneration and Language in Primary Progressive Aphasia
Study Start Date :	May 2007
Estimated Primary Completion Date :	April 2027
Estimated Study Completion Date :	April 2027

Resource links provided by the National Library of Medicine

MedlinePlus Genetics related topics: CHMP2B-related frontotemporal dementia Frontotemporal dementia with parkinsonism-17 Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia GRN-related frontotemporal lobar degeneration

MedlinePlus related topics: Aphasia

Genetic and Rare Diseases Information Center resources: Primary Progressive Aphasia Frontotemporal Dementia Frontotemporal Dementia, Ubiquitin-positive Semantic Dementia Progressive Non-fluent Aphasia Behavioral Variant of Frontotemporal Dementia

U.S. FDA Resources

Groups and Cohorts

Group/Cohort
PPA (Primary Progressive Aphasia) Individuals with primary progressive aphasia
Control Individuals with no diagnosis of any type of dementia

Outcome Measures

Primary Outcome Measures :

Neuropsychological variables [ Time Frame: Immediately after testing and at two years post-testing ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:	Child, Adult, Older Adult
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Participants with PPA will be recruited from the Northwestern University Alzheimer's Disease Center Core registry, the Northwestern University Neurobehavior and Memory Clinic, and from those who contact the center that are interested in PPA research.

Criteria

Inclusion Criteria:

Diagnosis of primary progressive aphasia
Right-handed
Native English speaker
Visual acuity of 20/30 corrected
Adequate hearing to follow conversation
Safe for an MRI scan

Exclusion Criteria:

Left-handedness
Claustrophobia
Presence of significant medical illness that initially or in the future could interfere with continued participation in the study

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00537004

Contacts

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Contact: Seyi Adeolu	312-503-2398	PPA.Research@northwestern.edu

Locations

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United States, Illinois
Northwestern University	Recruiting
Chicago, Illinois, United States, 60611
Contact: Seyi Adeolu 312-503-2398 PPA.Research@northwestern.edu
Principal Investigator: M.-Marsel Mesulam, MD

Sponsors and Collaborators

Northwestern University

National Institute on Aging (NIA)

Investigators

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Principal Investigator:	Marsel Mesulam, MD	Northwestern University Feinberg School of Medicine

More Information

Additional Information:

PPA Research at Northwestern University This link exits the ClinicalTrials.gov site

Publications:

Mesulam MM. Slowly progressive aphasia without generalized dementia. Ann Neurol. 1982 Jun;11(6):592-8. doi: 10.1002/ana.410110607.

Weintraub S, Rubin NP, Mesulam MM. Primary progressive aphasia. Longitudinal course, neuropsychological profile, and language features. Arch Neurol. 1990 Dec;47(12):1329-35. doi: 10.1001/archneur.1990.00530120075013.

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Mesulam MM, Coventry C, Kuang A, Bigio EH, Mao Q, Flanagan ME, Gefen T, Sridhar J, Geula C, Zhang H, Weintraub S, Rogalski EJ. Memory Resilience in Alzheimer Disease With Primary Progressive Aphasia. Neurology. 2021 Feb 9;96(6):e916-e925. doi: 10.1212/WNL.0000000000011397. Epub 2021 Jan 13.

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Responsible Party:	Marsel Mesulam, Director, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University
ClinicalTrials.gov Identifier:	NCT00537004
Other Study ID Numbers:	IA0125 R01AG077444 ( U.S. NIH Grant/Contract )
First Posted:	September 28, 2007 Key Record Dates
Last Update Posted:	January 25, 2023
Last Verified:	January 2023

Keywords provided by Marsel Mesulam, Northwestern University:


primary progressive aphasia frontotemporal dementia semantic dementia	progressive nonfluent aphasia progressive aphasia frontotemporal lobar degeneration

Additional relevant MeSH terms:

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Aphasia Aphasia, Primary Progressive Pick Disease of the Brain Frontotemporal Dementia Speech Disorders Language Disorders Communication Disorders Neurobehavioral Manifestations Neurologic Manifestations Nervous System Diseases	Dementia Brain Diseases Central Nervous System Diseases Neurocognitive Disorders Mental Disorders Frontotemporal Lobar Degeneration TDP-43 Proteinopathies Neurodegenerative Diseases Proteostasis Deficiencies Metabolic Diseases

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