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Schizophrenia Sensory Gating Deficit With Quetiapine

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00536783
First Posted: September 28, 2007
Last Update Posted: December 31, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
AstraZeneca
Information provided by:
New Mexico VA Healthcare System
  Purpose
The purpose of this study is the use of magnetoencephalography or MEG (a machine that measures magnetic activity in your brain) and electroencephalography or EEG (a technique that measures electrical activity in your brain) to study how sounds are processed in individuals with schizophrenia after three months of taking the antipsychotic medication quetiapine.

Condition Intervention
Schizophrenia Drug: Quetiapine

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Schizophrenia Sensory Gating Deficit With Quetiapine

Resource links provided by NLM:


Further study details as provided by New Mexico VA Healthcare System:

Estimated Enrollment: 20
Study Start Date: April 2004
Study Completion Date: March 2006
Detailed Description:
.Problems with attention and perception are core features of schizophrenia and are hypothesized to result from defects in the filtering or gating of sensory input. Examination of this requires neuoimaging techniques with high temporal resolution. High-density EEG and MEG in combination with structural magnetic resonance imaging (sMRI) are used to map sensory gating. In a number of recent studies patient treated with novel antipsychotics have been shown to have P50 gating ratios resembling those of normal controls rather than that of schizophrenia subjects treatment with conventional antipsychotics. To date, there is no literature on the effects of quetiapine on sensory gating. Subjects who meet all inclusion criteria and have been on a stable dose of quetiapine for three months will receive a clinical interview, an MRI, MEG, and neuropsychological testing to determine if patients with schizophrenia who are treated with quetiapine will demonstrate a sensory gating ratio similar to normal controls, indicating no deficit in sensory gating.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 18 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Patient Population

  • Diagnosis of Schizophrenia as determine by the Structured Clinical Interview for DSM-IV
  • No comorbid diagnosis of PTSD
  • responders to quetiapine, determined by continuous treatment at the same dose of quetiapine and absence of psychiatric hospitalization for at least 3 months
  • No history of drug dependency in their lifetime
  • No history of alcohol or other substance abuse in the 6 months prior to entry into the study
  • No history of head injury with loss of consciousness for more than 5 minutes
  • No history of seizure disorder
  • No mood stabilizing agents
  • Between 18-65 and
  • Able to sign informed consent

Normal Controls

  • Matched in age and gender to patient population
  • No history of psychiatric dysfunction or alcohol or other substance dependence in their lifetime as determine by the SCID
  • No history of alcohol or other substance abuse in the previous 6 months
  • No family history of psychotic disorder in first degree relatives as assessed by the FH-RDC diagnostic interview
  • No history of head injury with loss of consciousness for more than 5 minutes
  • No history of seizure disorder
  • Between 18-65
  • Able to sign informed consent

Exclusion Criteria:

Subjects will be excluded from participating in this study if they:

  • Require treatment with a mood stabilizer
  • Have had an inpatient hospitalization in the past 3 months
  • Have a history of a neurological disorder
  • Have any other axis I diagnosis besides schizophrenia
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00536783


Locations
United States, New Mexico
New Mexico VA Healthcare System
Albuquerque, New Mexico, United States, 87108
Sponsors and Collaborators
New Mexico VA Healthcare System
AstraZeneca
Investigators
Principal Investigator: Jose M Canive, MD New Mexico VA Heathcare System / BRINM
  More Information

Additional Information:
ClinicalTrials.gov Identifier: NCT00536783     History of Changes
Other Study ID Numbers: 0072
. IRUSQUET0332
First Submitted: September 27, 2007
First Posted: September 28, 2007
Last Update Posted: December 31, 2007
Last Verified: September 2007

Keywords provided by New Mexico VA Healthcare System:
Psychiatry
Antipsychotic
Psychopharmacology
Clinical Trial
Open Label
Schizophrenia
Sensory Gating
Attention
Memory

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Quetiapine Fumarate
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Physiological Effects of Drugs
Psychotropic Drugs