Topical Ocular Mecamylamine in Diabetic Macular Edema (DME)

This study has been completed.
Juvenile Diabetes Research Foundation
Information provided by:
CoMentis Identifier:
First received: September 26, 2007
Last updated: April 3, 2008
Last verified: April 2008
This is an open-label study evaluating the safety and tolerability of topical ocular mecamylamine given twice a day in patients with diabetic macular edema (DME). Patients will be treated for 12 weeks.

Condition Intervention Phase
Diabetic Macular Edema
Drug: mecamylamine
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Phase 2 Study of the Safety and Bioactivity of Topical Ocular Mecamylamine for the Treatment of Diabetic Macular Edema (DME)

Resource links provided by NLM:

Further study details as provided by CoMentis:

Study Start Date: September 2007
Study Completion Date: April 2008
Intervention Details:
    Drug: mecamylamine
    topical ocular drops

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • macular edema due to diabetic retinopathy

Exclusion Criteria:

  • vision loss from other ocular disease
  • intraocular surgery within 3 months
  • intraocular anti-VEGF or steroids within 3 months
  • HbA1c >12
  Contacts and Locations
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Please refer to this study by its identifier: NCT00536692

United States, California
East Bay Retina Consultants, Inc.
Oakland, California, United States, 94609
United States, Maryland
Johns Hopkins School of Medicine / Wilmer Eye Institute
Baltimore, Maryland, United States, 21287
United States, Massachusetts
Ophthalmic Consultants of Boston
Boston, Massachusetts, United States, 02114
Sponsors and Collaborators
Juvenile Diabetes Research Foundation
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00536692     History of Changes
Other Study ID Numbers: ATG003-202 
Study First Received: September 26, 2007
Last Updated: April 3, 2008
Health Authority: United States: Food and Drug Administration

Keywords provided by CoMentis:
macular edema

Additional relevant MeSH terms:
Macular Edema
Eye Diseases
Macular Degeneration
Retinal Degeneration
Retinal Diseases
Signs and Symptoms
Antihypertensive Agents
Autonomic Agents
Cardiovascular Agents
Cholinergic Agents
Cholinergic Antagonists
Ganglionic Blockers
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Nicotinic Antagonists
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses processed this record on May 05, 2016