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Tracheal Mechanics During Bronchoscopy

This study has been completed.
Information provided by (Responsible Party):
Stephen Loring, Beth Israel Deaconess Medical Center Identifier:
First received: September 26, 2007
Last updated: March 8, 2017
Last verified: February 2010
The main purpose of this study is use a new type of measurement to help decide what kind of therapy would help people with a collapsing windpipe or tracheomalacia.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Tracheal Mechanics During Bronchoscopy

Resource links provided by NLM:

Further study details as provided by Stephen Loring, Beth Israel Deaconess Medical Center:

Enrollment: 145
Actual Study Start Date: March 1, 1999
Study Completion Date: June 2009
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Patients with cough and/or shortness of breath who may have windpipe collapse.
Healthy adults
Subjects without symptoms for comparison.
Patients with cough and/or shortness of breath who may have windpipe collapse.

Detailed Description:
This study is to obtain new information about the pressures required to collapse the trachea in patients with and without obstructive pulmonary disease and to describe the relationship between pressures and airflow obstruction. This information will provide normative data not currently available and would establish whether tracheal collapse is due to tracheomalacia. The data may lead to better ways of predicting if a patient would benefit from procedures to prevent tracheal collapse.

Ages Eligible for Study:   21 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy control subjects recruited from subjects volunteering for CT or bronchoscopic studies and patients referred for evaluation of possible tracheomalacia.

Inclusion Criteria:

  • Suspicion of tracheal collapse undergoing bronchoscopy
  • Healthy control subject undergoing bronchoscopy for another purpose.

Exclusion Criteria:

  • Esophageal pathology
  • Tracheostomy
  • inability to follow commands
  Contacts and Locations
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Please refer to this study by its identifier: NCT00536315

United States, Massachusetts
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Sponsors and Collaborators
Beth Israel Deaconess Medical Center
Principal Investigator: Stephen H Loring, M.D. Beth Israel Deaconess Medical Center
  More Information

Responsible Party: Stephen Loring, Professor of Anaesthesia, Beth Israel Deaconess Medical Center Identifier: NCT00536315     History of Changes
Other Study ID Numbers: 2001P001418
Study First Received: September 26, 2007
Last Updated: March 8, 2017

Keywords provided by Stephen Loring, Beth Israel Deaconess Medical Center:

Additional relevant MeSH terms:
Cartilage Diseases
Musculoskeletal Diseases
Tracheal Diseases
Respiratory Tract Diseases
Musculoskeletal Abnormalities
Congenital Abnormalities
Connective Tissue Diseases
Bronchial Diseases processed this record on May 25, 2017