Working... Menu
Trial record 85 of 179 for:    "Panic Disorder"

Evaluating the Relationship Between Tobacco Use, Anxiety Sensitivity, and Panic in Adolescents

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00535964
Recruitment Status : Completed
First Posted : September 27, 2007
Last Update Posted : April 11, 2013
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Rosemary Ruff, University of Arkansas, Fayetteville

Brief Summary:
This study will determine whether there is a relationship between tobacco use and a heightened response to panic-producing events among adolescents. This study is fundamental research. It was not a Clinical Trial.

Condition or disease
Panic Disorder

Detailed Description:

Growing up is hard enough, and adolescence can be a particularly stressful time in people's lives as they adjust to the transition from childhood to adulthood. Peer pressure can add to this anxiety, making it more likely for teens to take part in risky behaviors such as smoking cigarettes. Every day, more than 4,000 teens smoke their first cigarette and nearly half of those teens will become regular, daily smokers. Cigarette smoking is associated with a multitude of health risks, including an increased likelihood of experiencing panic attacks, anxiety disorders, and depression. This study will evaluate a group of teens, ranging from those who have never smoked to those who smoke daily, to determine whether there is a relation between adolescent smoking history and their vulnerability to panic-producing situations.

Participants in this study will undergo a brief medical screening, followed by a short interview that will include several questionnaires regarding emotions, experiences, and personal habits. Participants will then attend a series of laboratory assessments for 1 hour. The first assessment will include a 3-minute voluntary hyperventilation procedure in which participants will be directed when to breathe in and when to breathe out, at a faster rate than normal. Participants will then take part in two computerized tasks: one will be a computerized task that involves blowing up a balloon and deciding when to quit before the balloon pops; the other task will involve choosing hypothetical amounts of money now or after a period of delay. During the laboratory assessments, all participants will have electrodes attached to their bodies and sensors around their chests to measure heart rate, palm sweating, and muscle tension. Results from this study will be used to evaluate the association between smoking and increased panic levels under stressful conditions among adolescents.

Layout table for study information
Study Type : Observational
Actual Enrollment : 180 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Anxiety Sensitivity, Tobacco Use, and Panic Among Adolescents
Study Start Date : June 2007
Actual Primary Completion Date : April 2009
Actual Study Completion Date : April 2009

Resource links provided by the National Library of Medicine

Psychologically healthy adolescents, evenly divided across the various stages of smoking uptake

Primary Outcome Measures :
  1. Relationship between cigarette smoking and panic vulnerability [ Time Frame: Measured at completion of laboratory testing analysis ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   12 Years to 17 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Participants will be 180 psychologically healthy adolescents, evenly divided across the various stages of smoking uptake (i.e., non-smokers, tried smoking, experimenters, regular smokers, and daily smokers).

Inclusion Criteria:

  • Adolescents, ranging from those who have never smoked to those who smoke daily

Exclusion Criteria:

  • Current or past diagnosis of a panic disorder
  • Acute or chronic cardiopulmonary or respiratory illness (e.g., asthma or bronchitis)
  • Pregnant

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00535964

Layout table for location information
United States, Arkansas
University of Arkansas
Fayetteville, Arkansas, United States, 72701
Sponsors and Collaborators
University of Arkansas, Fayetteville
National Institute of Mental Health (NIMH)
Layout table for investigator information
Principal Investigator: Ellen W. Leen-Feldner, PhD University of Arkansas

Layout table for additonal information
Responsible Party: Rosemary Ruff, Director of Research Compliance, University of Arkansas, Fayetteville Identifier: NCT00535964     History of Changes
Other Study ID Numbers: R03MH077692 ( U.S. NIH Grant/Contract )
R03MH077692 ( U.S. NIH Grant/Contract )
First Posted: September 27, 2007    Key Record Dates
Last Update Posted: April 11, 2013
Last Verified: April 2013

Keywords provided by Rosemary Ruff, University of Arkansas, Fayetteville:
Cigarette Smoking
Tobacco Use
Anxiety Sensitivity (AS)

Additional relevant MeSH terms:
Layout table for MeSH terms
Panic Disorder
Immune System Diseases
Anxiety Disorders
Mental Disorders