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Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas

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ClinicalTrials.gov Identifier: NCT00532402
Recruitment Status : Completed
First Posted : September 20, 2007
Last Update Posted : October 30, 2012
Sponsor:
Information provided by (Responsible Party):
Martin Grossherr, University of Luebeck

Brief Summary:

This study should compare the propofol concentration in breathing gas and in plasma (before and) after lung passage. Propofol concentrations in breathing gas are continuously measured by a sensor. For comparison a discontinuous method is used. Neurophysiologic parameters for determination of depth of anesthesia are compared to the continuous measured propofol concentration in breathing gas.

Study hypothesis: continuous measured propofol concentration in breathing gas correlates to propofol concentration in plasma and depth of anaesthesia.


Condition or disease
General Anesthesia

Study Type : Observational
Estimated Enrollment : 16 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas - Compared With Propofol Concentration in Plasma (Before and) After Lung Passage and Neurophysiological Parameters
Study Start Date : September 2007
Actual Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Anesthesia
Drug Information available for: Propofol





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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients having general anesthesia for cardiac and non-cardiac operation
Criteria

Inclusion Criteria:

  • Patient destined for general anesthesia

Exclusion Criteria:

  • Heart insufficiency NYHA IV
  • Allergy to propofol

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00532402


Locations
Germany
Dept. of Anesthesiology , UK-SH, Campus Luebeck
Luebeck, Schleswig-Holstein, Germany, D-23538
Dept. of Anesthesiology, UK-SH, Campus Luebeck
Luebeck, Schleswig-Holstein, Germany, D-23538
Sponsors and Collaborators
University of Luebeck
Investigators
Study Director: Hartmut Gehring, MD, PhD Dept of Anesthesiology, UK-SH, Campus Luebeck

Publications of Results:
Responsible Party: Martin Grossherr, Consultant, University of Luebeck
ClinicalTrials.gov Identifier: NCT00532402     History of Changes
Other Study ID Numbers: P-A-S-1
First Posted: September 20, 2007    Key Record Dates
Last Update Posted: October 30, 2012
Last Verified: October 2012

Keywords provided by Martin Grossherr, University of Luebeck:
Monitoring
Breathing Gas
Propofol

Additional relevant MeSH terms:
Respiratory Aspiration
Respiration Disorders
Respiratory Tract Diseases
Pathologic Processes
Propofol
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Intravenous
Anesthetics, General
Anesthetics