Gallbladder Cholesterolosis, Body Mass Index and Serum Cholesterol and Triglycerides

This study has been completed.
Information provided by:
Cirujanos la Serena Identifier:
First received: September 10, 2007
Last updated: August 9, 2011
Last verified: July 2009

Cholesterolosis is a common finding in biopsy specimens of gallbladders surgically removed for cholelithiasis.

To the best of the investigators knowledge no study has analyzed the relationships of Body Mass Index, serum Cholesterol and Triglycerides and gallbladder cholesterolosis.

The purpose of this study is to analyze and find relations between gallbladder cholesterolosis, Body Mass Index, serum cholesterol and triglycerides.

Condition Intervention
Gallbladder Cholesterolosis
Other: Specimen biopsy and serum laboratory tests

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Association of Gallbladder Cholesterolosis to Body Mass Index and Levels of Serum Cholesterol and Triglycerides.

Resource links provided by NLM:

Further study details as provided by Cirujanos la Serena:

Enrollment: 406
Study Start Date: March 2008
Study Completion Date: July 2009
Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
I. Patients with gallbladder cholesterolosis and symptomatic cholelithiasis
Other: Specimen biopsy and serum laboratory tests

Biopsy of the surgical specimens (gallbladder) submitted after cholecystectomy

Laboratory tests measuring levels of plasma total cholesterol and triglycerides

II. Patients without gallbladder cholesterolosis and with symptomatic cholelithiasis
Other: Specimen biopsy and serum laboratory tests

Biopsy of the surgical specimens (gallbladder) submitted after cholecystectomy

Laboratory tests measuring levels of plasma total cholesterol and triglycerides

Detailed Description:

A prospective database including the following variables was filled out:

  • Age
  • Gender
  • Diagnosis
  • Weight
  • Height
  • Body Mass Index
  • Histopathological results (Biopsy)
  • Serum cholesterol
  • Serum triglycerides

All elective patients older than 15 years of age submitted to cholecystectomy for symptomatic gallstones were included. Plasma cholesterol and triglycerides levels were measured 5 to 7 days before surgery. Only patients with chronic cholecystitis and with cholesterolosis according to the histology of the surgical specimen were included, we did not include any patient with acute cholecystitis or gallbladder cancer.


Ages Eligible for Study:   15 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients operated on elective basis for symtomatic gallbladder lithiasis

Inclusion Criteria:

  • Patients submitted to elective cholecystectomy
  • Histopathological report of gallbladder cholesterolosis
  • Histopathological report of chronic cholecystitis
  • Patients older than 15 years of age

Exclusion Criteria:

  • Patients younger than 15 years of age
  • Pathological report missing from the hospital records
  Contacts and Locations
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Please refer to this study by its identifier: NCT00528632

Hospital De La Serena
La Serena, Iv Region, Chile, IV REGION
Sponsors and Collaborators
Cirujanos la Serena
Principal Investigator: Marcelo A Beltran, MD Hospital De La Serena
Study Director: Carlos Barria, MD Hospital De La Serena - HISTOMED
  More Information

No publications provided

Responsible Party: MARCELO A. BELTRAN, MD, Hospital De La Serena Identifier: NCT00528632     History of Changes
Other Study ID Numbers: HLS-0012-09-07
Study First Received: September 10, 2007
Last Updated: August 9, 2011
Health Authority: Chile: Instituto de Salud Pública de Chile

Keywords provided by Cirujanos la Serena:
Serum cholesterol
Body Mass Index

Additional relevant MeSH terms:
Biliary Tract Diseases
Digestive System Diseases
Gallbladder Diseases
Pathological Conditions, Anatomical processed this record on November 25, 2015