Pilot Study to Identify the Influence of Genetic Profile Aberrations on Patients With Recurrent Hernias
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|ClinicalTrials.gov Identifier: NCT00527670|
Recruitment Status : Terminated (PI left institution)
First Posted : September 11, 2007
Last Update Posted : August 8, 2016
|Condition or disease||Intervention/treatment|
|Pathological Processes||Procedure: Normal Controls Procedure: Recurrent Hernia|
This is a prospective, case control pilot study with the aim of identifying potential genetic influences on recurrent hernia formation. Patients with recurrent abdominal hernias will be compared with normal control subjects. The study endpoints will compare tissue collagen I/III ratios between the groups. It will also use gene chip technology to identify potential differences in gene expression between the two groups, followed by confirmation of the differential expression using RT-PCR.
Patients will be enrolled from the surgical clinic population. If they consent to the study, both the hernia group and the control group will have 0.5 x 0.5 x 0.1 cm3 pieces of skin and fascia collected at the time of their surgery. A small piece of tissue will be used for immunofluorescene to study collagen I/III ratios. RNA will be extracted from the rest of the tissue for the genetic studies.
|Study Type :||Observational|
|Actual Enrollment :||41 participants|
|Observational Model:||Case Control|
|Official Title:||Pilot Study to Identify the Influence of Genetic Profile Aberrations on Patients With Recurrent Hernias|
|Study Start Date :||August 2007|
|Actual Primary Completion Date :||November 2010|
|Actual Study Completion Date :||November 2010|
Healthy patients undergoing laparoscopic surgery for cholelithiasis, appendicitis, and adrenalectomy.
Procedure: Normal Controls
The control group will have small slivers of tissue removed from the skin and abdomen during surgery to compare genomic information.
Patients presenting for laparoscopic repair of ventral or incisional hernias.
Procedure: Recurrent Hernia
This group will have small slivers of tissue removed from the skin and abdomen during hernia repair surgery to find genetic proof of hernias being inherited.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00527670
|United States, Missouri|
|University of Missouri Hospital and Clinics|
|Columbia, Missouri, United States, 65212|
|Principal Investigator:||Bruce Ramshaw, MD||University of Missouri-Columbia|