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Biomarker Analysis of Stress

This study has been completed.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS) Identifier:
First received: September 6, 2007
Last updated: April 13, 2015
Last verified: April 2015
Physiological changes can occur from different types of stress as induced by an infection, an environmental toxicant exposure, or an emotional disturbance. The stress-induced effects can modify health by lessening defense mechanisms as maintained by the immune system. The ability of different forms of stress to alter physiological processes (body functions) will be assessed by monitoring the blood profile of cell numbers and functions as well as the plasma protein content. It is anticipated that the pattern of blood changes will reflect the types of stress and the degree to which body functions could be altered by the stress.


Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Biomarker Signatures of Biological, Chemical, or Psychological Stress

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 50
Study Start Date: October 2007
Study Completion Date: May 2011
Primary Completion Date: May 2011 (Final data collection date for primary outcome measure)
Detailed Description:
Blood will be collected from patients with an ongoing infection that has lead to sepsis (systemic inflammation) as a index of major stress. The blood will be analyzed for the types of proteins that could alter immune system functions and affect organ functions, including cardiovascular effects due to blood vessel changes. This will be followed by analysis of stress effects on mice and mice that have been generated with human immune cells. The ability of stress to alter blood patterns will also be examined in mice with genetic modification of metallothionein expression, which is believe to influence oxidative stress.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients at Wadsworth Center with Sepsis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00527384

United States, New York
Wadsworth Center
Albany, New York, United States, 12201
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
Principal Investigator: David A. Lawrence, Ph.D. Wadsworth Center
  More Information Identifier: NCT00527384     History of Changes
Other Study ID Numbers: 16014-CP-001
Study First Received: September 6, 2007
Last Updated: April 13, 2015

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Stress processed this record on September 21, 2017