Pulse Corticosteroid Therapy and Effect on Brain Water Diffusivity
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|ClinicalTrials.gov Identifier: NCT00527176|
Recruitment Status : Unknown
Verified September 2007 by Cliniques universitaires Saint-Luc- Université Catholique de Louvain.
Recruitment status was: Recruiting
First Posted : September 10, 2007
Last Update Posted : September 10, 2007
In daily clinical use, pulse high dosis corticosteroids are used to treat cerebral edema in different pathological situations ( surgery, trauma, tumors...). Dehydration can theorically concern extra-cellular or intracellular water, or both.
The relative proportion of those two components are not known, as well their kinetics.
Diffusion Weighted Imaging ( DWI) is a none invasive and none toxic technique to study those phenomena.We can also study the diffusivity anisotropy not using a Gaussian distribution but rather a non- gaussian one, more close to the reality ( q Space Imaging ).
Finally, we can study the compartment redistribution between slow and rapid water molecules diffusion by bi-exponential decomposition of the diffusion signal, corresponding, theorically, respectively to the intra- and extra-cellular component.
Hypothesis : The high dosis steroid pulse therapy modifies or not the water free diffusion in DWI and qSI ? Is there a modification in the diffusivity of both rapid and slow component ?
|Condition or disease|
|Systemic Lupus Erythematosus|
|Study Type :||Observational|
|Observational Model:||Defined Population|
|Observational Model:||Natural History|
|Study Start Date :||September 2007|
|Study Completion Date :||September 2007|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00527176
|Contact: Thierry Duprez, MD||+ 32 2 764 29 firstname.lastname@example.org|
|Contact: Denis J Rommel, MDemail@example.com|
|Clinique Universitaire St LUC||Recruiting|
|Brussels, Belgium, 1200|
|Study Director:||Thierry Duprez, MD||Universite Catholique de Louvain|
|Principal Investigator:||Denis Rommel, MD||Universite Catholique de Louvain|