Pulse Corticosteroid Therapy and Effect on Brain Water Diffusivity
Recruitment status was: Recruiting
In daily clinical use, pulse high dosis corticosteroids are used to treat cerebral edema in different pathological situations ( surgery, trauma, tumors...). Dehydration can theorically concern extra-cellular or intracellular water, or both.
The relative proportion of those two components are not known, as well their kinetics.
Diffusion Weighted Imaging ( DWI) is a none invasive and none toxic technique to study those phenomena.We can also study the diffusivity anisotropy not using a Gaussian distribution but rather a non- gaussian one, more close to the reality ( q Space Imaging ).
Finally, we can study the compartment redistribution between slow and rapid water molecules diffusion by bi-exponential decomposition of the diffusion signal, corresponding, theorically, respectively to the intra- and extra-cellular component.
Hypothesis : The high dosis steroid pulse therapy modifies or not the water free diffusion in DWI and qSI ? Is there a modification in the diffusivity of both rapid and slow component ?
|Systemic Lupus Erythematosus|
|Study Design:||Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Please refer to this study by its ClinicalTrials.gov identifier: NCT00527176
|Contact: Thierry Duprez, MD||+ 32 2 764 29 email@example.com|
|Contact: Denis J Rommel, MDfirstname.lastname@example.org|
|Clinique Universitaire St LUC||Recruiting|
|Brussels, Belgium, 1200|
|Study Director:||Thierry Duprez, MD||Universite Catholique de Louvain|
|Principal Investigator:||Denis Rommel, MD||Universite Catholique de Louvain|