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Prone Position for Non-intubated Patients With Acute Respiratory Failure

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2011 by Karolinska University Hospital.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Johan Petersson, Karolinska University Hospital Identifier:
First received: September 6, 2007
Last updated: September 19, 2011
Last verified: September 2011
The study will test the hypothesis that the prone position can be used to reduce the need for intubation and mechanical ventilation in patients with acute respiratory failure.

Condition Intervention
Respiratory Failure
Other: Prone position

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Prone Position for Non-intubated Patients With Acute Respiratory Failure

Resource links provided by NLM:

Further study details as provided by Karolinska University Hospital:

Primary Outcome Measures:
  • Need for intubation and mechanical ventilation [ Time Frame: Duration of hospital stay ]

Estimated Enrollment: 24
Study Start Date: September 2007
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Treatment
Prone position + all conventional treatment.
Other: Prone position
Prone position during spontaneous breathing.
No Intervention: Control
Conventional treatment


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • bilateral pulmonary infiltrates or unilateral infiltrates involving more than one lobe on CXR
  • PaO2/FIO2 < 40 kPa
  • RR > 25, or attending intensivist considering likelihood of intubation > 50%

Exclusion Criteria:

  • unsuited for the prone position
  • fulfilled inclusion criteria for more than 5 days (120 h)
  • immunosuppression
  • chronic lung disease
  • decision of withdrawal or limitation of therapy
  • pulmonary infiltrates of cardiac origin
  • decreased GCS level
  • PaCO2 > 10
  • attending intensivist considering the patient unsuited for the prone position
  • BMI > 33
  Contacts and Locations
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Please refer to this study by its identifier: NCT00526981

Contact: Johan Petersson, MD +4685172066

Karolinska University Hospital Solna Recruiting
Stockholm, Sweden, 17176
Contact: Joha Petersson, MD    +46851772066   
Sponsors and Collaborators
Karolinska University Hospital
Principal Investigator: Johan Petersson, MD Karolinska Institutet
  More Information

Responsible Party: Johan Petersson, MD, PhD, Karolinska University Hospital Identifier: NCT00526981     History of Changes
Other Study ID Numbers: 2007/733-31/1-4
Study First Received: September 6, 2007
Last Updated: September 19, 2011

Additional relevant MeSH terms:
Respiratory Insufficiency
Respiratory Distress Syndrome, Adult
Respiration Disorders
Respiratory Tract Diseases
Lung Diseases processed this record on April 28, 2017