Behavioral and Physiological Effects of Visual Training

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00526942
Recruitment Status : Unknown
Verified September 2007 by Posit Science Corporation.
Recruitment status was:  Recruiting
First Posted : September 10, 2007
Last Update Posted : September 11, 2007
University of San Francisco
Information provided by:
Posit Science Corporation

Brief Summary:
The primary objective of this study is to evaluate the learnability of a 3 week, 40 minutes per day, 5 day per week, computer-based visual training exercise by healthy mature individuals undergoing normal aging.

Condition or disease Intervention/treatment Phase
Healthy Behavioral: SAAGE-designed, visual memory-based cognitive training Phase 1 Phase 2

Detailed Description:

Virtually all adults will suffer a decline in their cognitive capacities to some degree. Typically, cognitive decline is characterized by a slow, progressive decline in abilities (frequently in memory, attention, inhibition and speed of processing) relative to younger adults, commonly called normal aging, age-associated memory impairment, age-consistent memory impairment, benign senescent forgetfulness, late-life forgetfulness, ageing-associated cognitive decline, and the preferred term, age-related cognitive decline (ARCD) As virtually all adults experience a reduction in their cognitive abilities with age, ARCD has generally been considered to be a normal, inevitable, and irreversible part of aging; and the extremely severe forms of pathological cognitive decline (e.g., Alzheimer's disease, AD) have dominated therapeutic research in this area. However, ARCD represents an important cause of quality of life decline in almost every older adult, as the impact of forgetfulness and mental slowing increasingly change the abilities of individuals to successfully manage their day-to-day activities. Therapeutic approaches targeting the specific problems of ARCD in normal aging (as opposed to the pathological problems of AD) would unto themselves represent important clinical advances.

This trial investigates the effects of a computer-based visual training exercise built on the principles of positive brain plasticity and designed for use by healthy mature individuals. The program is specifically designed to improve the fidelity of sensory representations in early visual cortex.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 54 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Computer-Based Cognitive Training in Normal Healthy Aging: Pilot Study of Behavioral and Physiological Effects of Visual Sweeps Training Exercise, 2-Arm Model
Study Start Date : August 2007
Estimated Study Completion Date : August 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Memory
U.S. FDA Resources

Arm Intervention/treatment
No Intervention: I
No contact control (NCC)
Experimental: II
Computerized, SAAGE-designed, visual memory-based cognitive training
Behavioral: SAAGE-designed, visual memory-based cognitive training
Training sessions take 40 minutes per day, five days per week for a total goal of 15, 40-minute sessions.
Other Name: Hawkeye

Primary Outcome Measures :
  1. Improvement in visual memory assessment after training or no-contact period. [ Time Frame: 6-8 weeks ]

Secondary Outcome Measures :
  1. Improvement on at least 1 of the Computerized Visual Attention, Speed and Memory Tests conducted. [ Time Frame: 6-8 weeks ]
  2. Improvement on the computerized cognitive assessments. [ Time Frame: 6-8 weeks ]
  3. Improvement on exercise-based assessments. [ Time Frame: 6-8 weeks ]

Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Age 60 or older at the time of consent.
  • Mini-Mental Status Examination (MMSE) score of 26 or higher.
  • Adequate visual capacity adequate to read.
  • Adequate hearing capacity.
  • Willing and able to commit to study time requirements.

Exclusion Criteria:

  • Self-report of current diagnosis or history of major neurological illness.
  • Self-report of current diagnosis or history of psychiatric illness. c. History of psychiatric hospitalization in the past twenty years.
  • History of a stroke, transient ischemic attack (TIA) or traumatic brain injury within the past year; or lifetime history of stroke, TIA, or traumatic brain injury that has left residual expressive or receptive language problems. - Fibromyalgia or symptoms of severe tremor.
  • Self-report of current substance abuse, including alcoholism.
  • Current useof medications with substantial CNS effects. Inappropriate behaviors during screening or baseline visits.
  • Inability to perform behavioral evaluations.
  • Participant is not capable of giving informed consent or unable to comprehend and/or follow instructions.
  • Participant is enrolled in a concurrent clinical study that could affect the outcome of this study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00526942

Contact: Daniel Tinker, BS 4153943100 ext 3541
Contact: Cate Stasio, BA 4153943100 ext 3546

United States, California
Posit Science Corporation Recruiting
San Francisco Bay Area, California, United States, 94104
Contact: Daniel Tinker, BS    415-394-3100 ext 3541   
Contact: Cate Stasio, BA    4153943100 ext 3546   
Principal Investigator: Joseph L Hardy, PhD         
Sub-Investigator: Daniel Tinker, BS         
Sponsors and Collaborators
Posit Science Corporation
University of San Francisco
Principal Investigator: Joseph L Hardy, PhD Posit Science Corporation