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Measuring Herpes Zoster and PHN Associated Burden of Illness and Health Care Utilization Costs in Thailand

This study has been completed.
Information provided by (Responsible Party):
Punnee Pitisuttithum, Mahidol University Identifier:
First received: September 7, 2007
Last updated: September 21, 2015
Last verified: September 2015

Total 7 institutions will be recruited i.e. Clinical Infectious Disease Research Unit Department of Clinical Tropical Medicine, Faculty of Tropical Medicine Mahidol University,Bamrasnaradura Infectious Disease Institute

,Pramonkutklao Hospital,Rajavithi Hospital,NationalCancerInstitute,Institute of Dermatology,Raj Pracha Samasai Institute


  • Measure the burden of illness due to herpes zoster (Zoster) and post-herpetic neuralgia (PHN) (severity and duration);
  • Assess the quality of life (QoL) and quality adjusted life years (QALY) lost due to Zoster and PHN;
  • Describe health care resource utilization associated with Zoster and PHN;
  • Describe the direct and indirect costs per case of Zoster and PHN

Herpes Zoster

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Measuring Herpes Zoster and Post-Herpetic Neuralgia Associated Burden of Illness and Health Care Utilization and Costs in Thailand

Resource links provided by NLM:

Further study details as provided by Punnee Pitisuttithum, Mahidol University:

Enrollment: 180
Study Start Date: May 2007
Study Completion Date: July 2008
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Elderly patients
HIV infected patients
Immunosuppressed patients

Detailed Description:

This will be a prospective cohort study of patients presenting with Zoster rash in 7 specialized institutions in Thailand.

Subjects will be entered in the cohort at the time of presentation with Zoster rash. After the baseline assessment (day 0) that will be conducted at the investigator's office there will be 4 assessments (prospective part of the study) that will be conducted at day 7, month 1, month 3 and month 6.

We expect that there will be approximately 150 patients included in the study cohort. Cohort assembly will take place between April 2007 and October 2007.

The study will be conducted in 3 groups

Eligible patients for each group will include

  • Group A: Both male and female patients ≥ 50 years of age with Zoster rash.
  • Group B: Both HIV infected male and female patients ≥ 20 years of age with Zoster rash.
  • Group C: Both Oncology male and female patients ≥ 20 years of age who on chemotherapy with Zoster rash.

Key exclusion criteria includes patient who refuses to sign informed consent.


Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
total of 180 clinically diagnosed herpes zoster patients, either aged ‡ 50 years and otherwise healthy, or ‡ 20 years with HIV infection, or ‡ 20 years and currently receiving chemotherapy or immunosuppressive agents.

Inclusion Criteria:

  • Physician confirmed diagnosis of Zoster rash
  • of onset of Zoster rash must be documented in the patient's chart.
  • Patient is capable of understanding the study and the content of the consent form and has agreed to participate in the study by signing the informed consent.
  • Patient will be available for the study follow up period

Exclusion Criteria:

  • no specific exclusion criteria
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Please refer to this study by its identifier: NCT00526864

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University
Bangkok, Thailand, 10400
Sponsors and Collaborators
Mahidol University
Principal Investigator: Punnee Pitisuttithum, Professor Department of Clinical Tropical Medicine, Faculty of Tropical Medicine
  More Information

Responsible Party: Punnee Pitisuttithum, Professor, Mahidol University Identifier: NCT00526864     History of Changes
Other Study ID Numbers: MUTM2007-035
Study First Received: September 7, 2007
Last Updated: September 21, 2015

Keywords provided by Punnee Pitisuttithum, Mahidol University:
Burden of Illness for Herpes zoster in Thailand.

Additional relevant MeSH terms:
Herpes Zoster
Herpesviridae Infections
DNA Virus Infections
Virus Diseases processed this record on May 25, 2017