Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion
Recruitment status was: Recruiting
Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury.
Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation
|Ischemia/Reperfusion Injury||Drug: Sevoflurane (Preconditioning)||Phase 4|
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers|
- marker expression on blood cells [ Time Frame: December 2008 ]
|Study Start Date:||January 2005|
|Estimated Study Completion Date:||December 2008|
|Estimated Primary Completion Date:||December 2008 (Final data collection date for primary outcome measure)|
Drug: Sevoflurane (Preconditioning)
Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations.
Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00526695
|Contact: 01 Studienregister MasterAdmins||+41 (0)44 255 11 11|
|University Hospital of Zurich||Recruiting|
|Contact: Michael Zaugg, MD email@example.com|
|Principal Investigator: Michael Zaugg, MD|
|Principal Investigator:||Michael Zaugg, PD Dr. med.||UniversitaetsSpital Zuerich|
|Principal Investigator:||Michael Zaugg, PD Dr. med.||University of Zurich|