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Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified July 2008 by University of Zurich.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00526695
First Posted: September 10, 2007
Last Update Posted: July 18, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Zurich
  Purpose

Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury.

Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation


Condition Intervention Phase
Ischemia/Reperfusion Injury Drug: Sevoflurane (Preconditioning) Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers

Resource links provided by NLM:


Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • marker expression on blood cells [ Time Frame: December 2008 ]

Estimated Enrollment: 10
Study Start Date: January 2005
Estimated Study Completion Date: December 2008
Estimated Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Sevoflurane (Preconditioning)
    Inhalation of sub-anesthetic doses of sevoflurane
Detailed Description:

Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations.

Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion criteria: male

  • Non-smoker
  • No asthma
  • NPO
  • Volunteer

Exclusion criteria:

  • Female
  • Chronic medication
  • Asthma
  • Smoking
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00526695


Contacts
Contact: 01 Studienregister MasterAdmins +41 (0)44 255 11 11

Locations
Switzerland
University Hospital of Zurich Recruiting
Zurich, Switzerland
Contact: Michael Zaugg, MD       michael.zaugg@usz.ch   
Principal Investigator: Michael Zaugg, MD         
Sponsors and Collaborators
University of Zurich
Investigators
Principal Investigator: Michael Zaugg, PD Dr. med. UniversitaetsSpital Zuerich
Principal Investigator: Michael Zaugg, PD Dr. med. University of Zurich
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Michael Zaugg, Anesthesiology, Univ. Hospital Zurich
ClinicalTrials.gov Identifier: NCT00526695     History of Changes
Other Study ID Numbers: 17-2005
First Submitted: August 27, 2007
First Posted: September 10, 2007
Last Update Posted: July 18, 2008
Last Verified: July 2008

Keywords provided by University of Zurich:
Ischemia/Reperfusion
Organ Protection
Anesthetics

Additional relevant MeSH terms:
Ischemia
Reperfusion Injury
Pathologic Processes
Vascular Diseases
Cardiovascular Diseases
Postoperative Complications
Sevoflurane
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs