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Brain Activation During Thermal Stimulation in Neuropathic Pain

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2007 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 3, 2007
Last updated: NA
Last verified: August 2007
History: No changes posted
Patients with peripheral neuropathy frequently exhibit treatment-refractory neuropathic pain. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following peripheral injury, the modulating effect on pain processing in brain by peripheral mechanisms remains elusive. Here, we will systematically compare the sensory symptoms and brain activation to painful heat stimulation applied to the foot dorsum between patients with peripheral neuropathy and healthy controls. Functional magnetic resonance imaging will be used to define brain activation to thermal stimulation with noxious heat and innocuous warm thermal stimuli applied by contact heat stimulator. Brain activation during thermal stimulation in patients with neuropathic pain will be clarified, and we will also analyze the potential relationships between the topography, quality and intensity of the different painful symptoms and the magnitude and pattern of brain activation during thermal stimulation. This will add in our understanding in the pathophysiology of brain modulation in pain and provide clinically useful message toward the potential therapeutics in the management of neuropathic pain.

Condition Intervention
Neuropathic Pain Device: contact heat evoked potential stimulator

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
Official Title: Brain Activation During Thermal Stimulation in Neuropathic Pain

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 80
Study Start Date: January 2007
Estimated Study Completion Date: July 2008
  Show Detailed Description


Ages Eligible for Study:   20 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Patients with peripheral neuropathy (defined according to the neuropathic symptoms and signs) and healthy volunteers will be recruited in this study

Exclusion Criteria:

  • subjects with structural brain lesions, pacemaker implantation, agoraphobia, and neurotic disorders.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00525018

Contact: Sung-Tsang Hsieh, MD, PhD 886-2-23123456 ext 8182

National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Sung-Tsang Hsieh, MD, PhD    886-2-23123456 ext 8182   
Sponsors and Collaborators
National Taiwan University Hospital
Study Director: Sung-Tsang Hsieh, MD, PhD Departments of Neurology,National Taiwan University Hospital
  More Information Identifier: NCT00525018     History of Changes
Other Study ID Numbers: 9561701022
Study First Received: September 3, 2007
Last Updated: September 3, 2007

Keywords provided by National Taiwan University Hospital:
Functional neuroimaging
Thermal sensation

Additional relevant MeSH terms:
Neurologic Manifestations
Nervous System Diseases
Peripheral Nervous System Diseases
Neuromuscular Diseases
Signs and Symptoms processed this record on August 23, 2017