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Brain Activation During Thermal Stimulation in Neuropathic Pain

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2007 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00525018
First Posted: September 5, 2007
Last Update Posted: September 5, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Taiwan University Hospital
  Purpose
Patients with peripheral neuropathy frequently exhibit treatment-refractory neuropathic pain. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following peripheral injury, the modulating effect on pain processing in brain by peripheral mechanisms remains elusive. Here, we will systematically compare the sensory symptoms and brain activation to painful heat stimulation applied to the foot dorsum between patients with peripheral neuropathy and healthy controls. Functional magnetic resonance imaging will be used to define brain activation to thermal stimulation with noxious heat and innocuous warm thermal stimuli applied by contact heat stimulator. Brain activation during thermal stimulation in patients with neuropathic pain will be clarified, and we will also analyze the potential relationships between the topography, quality and intensity of the different painful symptoms and the magnitude and pattern of brain activation during thermal stimulation. This will add in our understanding in the pathophysiology of brain modulation in pain and provide clinically useful message toward the potential therapeutics in the management of neuropathic pain.

Condition Intervention
Neuropathic Pain Device: contact heat evoked potential stimulator

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
Official Title: Brain Activation During Thermal Stimulation in Neuropathic Pain

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 80
Study Start Date: January 2007
Estimated Study Completion Date: July 2008
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Patients with peripheral neuropathy (defined according to the neuropathic symptoms and signs) and healthy volunteers will be recruited in this study

Exclusion Criteria:

  • subjects with structural brain lesions, pacemaker implantation, agoraphobia, and neurotic disorders.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00525018


Contacts
Contact: Sung-Tsang Hsieh, MD, PhD 886-2-23123456 ext 8182 sthsieh@ha.mc.ntu.edu.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Sung-Tsang Hsieh, MD, PhD    886-2-23123456 ext 8182    sthsieh@ha.mc.ntu.edu.tw   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Director: Sung-Tsang Hsieh, MD, PhD Departments of Neurology,National Taiwan University Hospital
  More Information

ClinicalTrials.gov Identifier: NCT00525018     History of Changes
Other Study ID Numbers: 9561701022
First Submitted: September 3, 2007
First Posted: September 5, 2007
Last Update Posted: September 5, 2007
Last Verified: August 2007

Keywords provided by National Taiwan University Hospital:
Pain
Functional neuroimaging
Neuropathy
Thermal sensation

Additional relevant MeSH terms:
Neuralgia
Pain
Neurologic Manifestations
Nervous System Diseases
Peripheral Nervous System Diseases
Neuromuscular Diseases
Signs and Symptoms