Brain Activation During Thermal Stimulation in Neuropathic Pain

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00525018
Recruitment Status : Unknown
Verified August 2007 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : September 5, 2007
Last Update Posted : September 5, 2007
Information provided by:
National Taiwan University Hospital

Brief Summary:
Patients with peripheral neuropathy frequently exhibit treatment-refractory neuropathic pain. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following peripheral injury, the modulating effect on pain processing in brain by peripheral mechanisms remains elusive. Here, we will systematically compare the sensory symptoms and brain activation to painful heat stimulation applied to the foot dorsum between patients with peripheral neuropathy and healthy controls. Functional magnetic resonance imaging will be used to define brain activation to thermal stimulation with noxious heat and innocuous warm thermal stimuli applied by contact heat stimulator. Brain activation during thermal stimulation in patients with neuropathic pain will be clarified, and we will also analyze the potential relationships between the topography, quality and intensity of the different painful symptoms and the magnitude and pattern of brain activation during thermal stimulation. This will add in our understanding in the pathophysiology of brain modulation in pain and provide clinically useful message toward the potential therapeutics in the management of neuropathic pain.

Condition or disease Intervention/treatment
Neuropathic Pain Device: contact heat evoked potential stimulator

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 80 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
Official Title: Brain Activation During Thermal Stimulation in Neuropathic Pain
Study Start Date : January 2007
Estimated Study Completion Date : July 2008

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Patients with peripheral neuropathy (defined according to the neuropathic symptoms and signs) and healthy volunteers will be recruited in this study

Exclusion Criteria:

  • subjects with structural brain lesions, pacemaker implantation, agoraphobia, and neurotic disorders.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00525018

Contact: Sung-Tsang Hsieh, MD, PhD 886-2-23123456 ext 8182

National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Sung-Tsang Hsieh, MD, PhD    886-2-23123456 ext 8182   
Sponsors and Collaborators
National Taiwan University Hospital
Study Director: Sung-Tsang Hsieh, MD, PhD Departments of Neurology,National Taiwan University Hospital Identifier: NCT00525018     History of Changes
Other Study ID Numbers: 9561701022
First Posted: September 5, 2007    Key Record Dates
Last Update Posted: September 5, 2007
Last Verified: August 2007

Keywords provided by National Taiwan University Hospital:
Functional neuroimaging
Thermal sensation

Additional relevant MeSH terms:
Neurologic Manifestations
Nervous System Diseases
Peripheral Nervous System Diseases
Neuromuscular Diseases
Signs and Symptoms