Metabolic Changes in Hypothyroid Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00524238
Recruitment Status : Completed
First Posted : September 3, 2007
Last Update Posted : February 12, 2008
Information provided by:
University of Aarhus

Brief Summary:

Hypothyroidism is a frequent condition in danish women, but often overlooked. Along with fatigue one of the main symptoms is weight gain as a result to significantly decreased energy expenditure.

This study was undertaken to elucidate changes in glucose, lipid and amino acid turnover in these patients.

Condition or disease Intervention/treatment Phase
Hypothyroidism Drug: L-thyroxine Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 22 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Impact of Hypothyroidism on Glucose, Lipid, and Amino Acid Turnover
Study Start Date : March 2004
Actual Primary Completion Date : August 2006
Actual Study Completion Date : August 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hypothyroidism

Arm Intervention/treatment
11 hypothyroid patients, newly diagnosed, examined before and after treatment
Drug: L-thyroxine
The hypothyroid patients receive usual treatment with L-thyroxine in our out patient clinic. The doctors there subscribe the medication, this study has no protocol regarding this, we observe the patients again after having been biochemically euthyroid for at least two months.

No Intervention: 2
10 healthy controls

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Newly diagnosed hypothyroidism with tsh over 40 mU/L, etiology chronic autoimmune thyroiditis
  • Healthy controls matched regarding sex, age and body mass index

Exclusion Criteria:

  • Pregnancy, breastfeeding

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00524238

Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Principal Investigator: Signe Gjedde, MD Aarhus University, Clinical Institute

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Signe Gjedde, MD, Medical Department M, Aarhus Sygehus Identifier: NCT00524238     History of Changes
Other Study ID Numbers: 20030196
First Posted: September 3, 2007    Key Record Dates
Last Update Posted: February 12, 2008
Last Verified: February 2008

Keywords provided by University of Aarhus:
glucose turnover
insulin resistance
lipid turnover
amino acid turnover

Additional relevant MeSH terms:
Thyroid Diseases
Endocrine System Diseases