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Metabolic Changes in Hypothyroid Patients

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ClinicalTrials.gov Identifier: NCT00524238
Recruitment Status : Completed
First Posted : September 3, 2007
Last Update Posted : February 12, 2008
Sponsor:
Information provided by:
University of Aarhus

Brief Summary:

Hypothyroidism is a frequent condition in danish women, but often overlooked. Along with fatigue one of the main symptoms is weight gain as a result to significantly decreased energy expenditure.

This study was undertaken to elucidate changes in glucose, lipid and amino acid turnover in these patients.


Condition or disease Intervention/treatment Phase
Hypothyroidism Drug: L-thyroxine Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 22 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Impact of Hypothyroidism on Glucose, Lipid, and Amino Acid Turnover
Study Start Date : March 2004
Actual Primary Completion Date : August 2006
Actual Study Completion Date : August 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hypothyroidism
U.S. FDA Resources

Arm Intervention/treatment
1
11 hypothyroid patients, newly diagnosed, examined before and after treatment
Drug: L-thyroxine
The hypothyroid patients receive usual treatment with L-thyroxine in our out patient clinic. The doctors there subscribe the medication, this study has no protocol regarding this, we observe the patients again after having been biochemically euthyroid for at least two months.
No Intervention: 2
10 healthy controls




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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Newly diagnosed hypothyroidism with tsh over 40 mU/L, etiology chronic autoimmune thyroiditis
  • Healthy controls matched regarding sex, age and body mass index

Exclusion Criteria:

  • Pregnancy, breastfeeding

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00524238


Locations
Denmark
Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Investigators
Principal Investigator: Signe Gjedde, MD Aarhus University, Clinical Institute

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Signe Gjedde, MD, Medical Department M, Aarhus Sygehus
ClinicalTrials.gov Identifier: NCT00524238     History of Changes
Other Study ID Numbers: 20030196
First Posted: September 3, 2007    Key Record Dates
Last Update Posted: February 12, 2008
Last Verified: February 2008

Keywords provided by University of Aarhus:
hypothyroidism
glucose turnover
clamp
insulin resistance
lipid turnover
amino acid turnover

Additional relevant MeSH terms:
Hypothyroidism
Thyroid Diseases
Endocrine System Diseases