Metabolic Changes in Hypothyroid Patients

This study has been completed.
Information provided by:
University of Aarhus Identifier:
First received: August 31, 2007
Last updated: February 7, 2008
Last verified: February 2008

Hypothyroidism is a frequent condition in danish women, but often overlooked. Along with fatigue one of the main symptoms is weight gain as a result to significantly decreased energy expenditure.

This study was undertaken to elucidate changes in glucose, lipid and amino acid turnover in these patients.

Condition Intervention
Drug: L-thyroxine

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Impact of Hypothyroidism on Glucose, Lipid, and Amino Acid Turnover

Resource links provided by NLM:

Further study details as provided by University of Aarhus:

Enrollment: 22
Study Start Date: March 2004
Study Completion Date: August 2006
Primary Completion Date: August 2006 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
11 hypothyroid patients, newly diagnosed, examined before and after treatment
Drug: L-thyroxine
The hypothyroid patients receive usual treatment with L-thyroxine in our out patient clinic. The doctors there subscribe the medication, this study has no protocol regarding this, we observe the patients again after having been biochemically euthyroid for at least two months.
No Intervention: 2
10 healthy controls


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Newly diagnosed hypothyroidism with tsh over 40 mU/L, etiology chronic autoimmune thyroiditis
  • Healthy controls matched regarding sex, age and body mass index

Exclusion Criteria:

  • Pregnancy, breastfeeding
  Contacts and Locations
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Please refer to this study by its identifier: NCT00524238

Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Principal Investigator: Signe Gjedde, MD Aarhus University, Clinical Institute
  More Information

No publications provided by University of Aarhus

Additional publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Signe Gjedde, MD, Medical Department M, Aarhus Sygehus Identifier: NCT00524238     History of Changes
Other Study ID Numbers: 20030196
Study First Received: August 31, 2007
Last Updated: February 7, 2008
Health Authority: Denmark: Ethics Committee

Keywords provided by University of Aarhus:
glucose turnover
insulin resistance
lipid turnover
amino acid turnover

Additional relevant MeSH terms:
Endocrine System Diseases
Thyroid Diseases processed this record on December 01, 2015