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Drainage of Tuberculous Pleural Effusions

This study has been completed.
Information provided by:
Taipei Medical University Hospital Identifier:
First received: August 31, 2007
Last updated: December 28, 2010
Last verified: December 2010
Tuberculous (TB) pleurisy can cause clinical symptoms and pleural fibrosis with resultant residual pleural thickening (RPT). Therapeutic thoracentesis or initial complete drainage in addition to anti-TB drugs have been tried to rapidly relieve dyspnea caused by effusion and to decrease the occurrence of RPT. However, contradictory results are reported without clear reasons. The researchers' hypothesis is that, in addition to anti-TB medications, early effective evacuation of inflammatory exudates with or without fibrinolytic agents may hasten resolution of pleural effusion, reduce the occurrence of RPT and finally improve long-term functional outcome in patients with TB pleurisy.

Condition Intervention
Tuberculous Pleurisy Procedure: Pigtail drainage

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Drainage of Tuberculous Pleural Effusions

Resource links provided by NLM:

Further study details as provided by Taipei Medical University Hospital:

Primary Outcome Measures:
  • Chest radiography, daily monitoring of the volume of fluid drained, the time needed for resolution of fever and dyspnea, and total amounts of fluid drained, and the length of chest drainage and hospitalization [ Time Frame: baseline, daily after treatment within admission ]

Secondary Outcome Measures:
  • Chest radiography and pulmonary function testing with spirometry [ Time Frame: At discharge and at 2, 4, 6, and 12 months ]

Enrollment: 64
Study Start Date: October 2003
Study Completion Date: December 2006
Primary Completion Date: October 2005 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosis of tuberculous pleurisy

Exclusion Criteria:

  • History of invasive procedures directed into the pleural cavity
  • Recent severe trauma, hemorrhage, or stroke; bleeding disorder or anticoagulant therapy
  • Use of streptokinase in the previous 2 years
  • Lack of clinical symptoms caused by effusions
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Please refer to this study by its identifier: NCT00524147

Taipei Medical University Hospital
Taipei, Taiwan
Sponsors and Collaborators
Taipei Medical University Hospital
Principal Investigator: Chi-Li Chung, MD Department of Internal Medicine, Taipei Medical University Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Chi-Li Chung, Department of Internal Medicine, Taipei Medical University Hospital Identifier: NCT00524147     History of Changes
Other Study ID Numbers: TMU92-AE1-B36
Study First Received: August 31, 2007
Last Updated: December 28, 2010

Keywords provided by Taipei Medical University Hospital:
loculated pleural effusion
pigtail drainage
pleural effusion
pleural thickening

Additional relevant MeSH terms:
Pleural Effusion
Tuberculosis, Pleural
Pleural Diseases
Respiratory Tract Diseases
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Respiratory Tract Infections processed this record on August 23, 2017