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Retrospective Analysis of Clinical Features in Ventriculoperitoneal Shunt Infectionsin Adults

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ClinicalTrials.gov Identifier: NCT00524108
Recruitment Status : Completed
First Posted : September 3, 2007
Last Update Posted : August 16, 2012
Sponsor:
Information provided by (Responsible Party):
University of Pittsburgh

Brief Summary:

The objectives of this study are:

  • To describe the incidence of clinical features in adults with internal ventriculoperitoneal (VP) shunt infections,
  • To determine the validity of laboratory parameters in adults with internal ventriculoperitoneal shunt infections and
  • To evaluate the relationship between the timing of shunt re-implantation with the rates of relapse and secondary infection.

Condition or disease
Ventriculoperitoneal Shunt Infection

Detailed Description:
Information from medical records of patients seen by the PI will be collected and analyzed to describe the incidence of clinical features in adults with internal ventriculoperitoneal shunt infections, to determine the validity of laboratory parameters in adults with internal ventriculoperitoneal shunt infections and to evaluate the relationship between the timing of shunt re-implantation with the rates of relapse and secondary infection.

Study Type : Observational
Actual Enrollment : 350 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Retrospective Analysis of Clinical Features in Ventriculoperitoneal Shunt Infections and Time to Re-Implantation in Adults
Study Start Date : August 2007
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010




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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
VP shunt infection
Criteria

Inclusion Criteria:

  • Adults (age >= 18 yrs) with VP shunts (ventriculoatrial [VA], and other cerebrospinal fluid [CSF] catheters will not be included).
  • Cases will include patients with a diagnosis of VP shunt infection.
  • Controls will be patients with a clinical suspicion of shunt infections with negative CSF cultures.

Exclusion Criteria:

  • Patients with meningitis from community acquired organisms (e.g. Streptococcus pneumoniae, Neisseria meningitidis, Listeria monocytogenes and Haemophilus Influenzae).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00524108


Locations
United States, Pennsylvania
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
University of Pittsburgh
Investigators
Principal Investigator: Adarsh Bhimraj, MD University of Pittsburgh

Responsible Party: University of Pittsburgh
ClinicalTrials.gov Identifier: NCT00524108     History of Changes
Other Study ID Numbers: PRO07080212
First Posted: September 3, 2007    Key Record Dates
Last Update Posted: August 16, 2012
Last Verified: August 2012

Keywords provided by University of Pittsburgh:
shunt
internal ventriculoperitoneal

Additional relevant MeSH terms:
Infection