Moderate Alcohol Consumption, Glucose Metabolism and Gastric Emptying
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|ClinicalTrials.gov Identifier: NCT00523861|
Recruitment Status : Completed
First Posted : September 3, 2007
Last Update Posted : September 14, 2007
|Condition or disease||Intervention/treatment||Phase|
|Lean Obese||Dietary Supplement: Moderate alcohol consumption||Not Applicable|
Purpose: The primary objective of this study is to investigate the effect of moderate daily alcohol consumption on hepatic glucose uptake and peripheral glucose storage. Secondly, the effect of moderate alcohol consumption on gastric emptying and postprandial wellness will be studied. These effects will be studied in apparently healthy, lean or overweight young men.
Design: Randomized, partially diet-controlled, placebo controlled cross-over design.
Subjects: Healthy male lean and obese volunteers aged between 18 and 40 years (n=18).
Intervention: During 2 periods of 21 days either white wine or white grape juice has to be consumed with the evening meal. The last 7 days of each period will be fully dietary controlled.
Treatment A: 375 ml of white wine (35 g alcohol) per day Treatment B: 375 ml of white grape juice per day
- Glucose metabolism: glucose uptake and peripheral glucose storage (measurement of isotopic enriched plasma glucose levels.
- Gastric emptying and postprandial wellness.
- Postprandial glycemic response and related factors (glucose, insulin, lactate, FFA, glucagon, ghrelin, CCK, GIP, GLP-1, PYY, triglycerides, total cholesterol, HDL cholesterol, LDL cholesterol, paracetamol (absorption test)
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||17 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Effect of Moderate Alcohol Consumption on Glucose Metabolism and Gastric Emptying in Healthy, Lean and Overweight Young Men|
|Study Start Date :||May 2005|
|Actual Study Completion Date :||June 2005|
- The primary objective of this study is to investigate the effect of moderate daily alcohol consumption on hepatic glucose uptake and peripheral glucose storage [ Time Frame: 3 weeks ]
- Secondly, the effect of moderate alcohol consumption on gastric emptying and postprandial wellness will be studied. [ Time Frame: 3 weeks ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00523861
|TNO Quality of Life|
|Zeist, Utrecht, Netherlands, 3700AJ|
|Principal Investigator:||Henk FJ Hendriks, PhD||Hendriks HFJ|