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The Genetics of Dilated Cardiomyopathy: A Quebec-Based Study

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ClinicalTrials.gov Identifier: NCT00523653
Recruitment Status : Unknown
Verified March 2008 by McGill University Health Center.
Recruitment status was:  Recruiting
First Posted : August 31, 2007
Last Update Posted : March 19, 2008
Sponsor:
Information provided by:
McGill University Health Center

Study Description
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Brief Summary:
Dilated cardiomyopathy (DCM) affects about 200,000 Canadians. Eighty percent of these cases are of unclear cause, often occuring in families. We believe that mutations in specific already-identified genes contribute to DCM in Quebec and that certain mutations may account for a significant proportion of cases due to the well-documented "founder effect". Two hundred patients with DCM followed in our Heart Function Clinic will be approached for one blood sample at their routine clinic visit to test this hypothesis. The samples will be tested in the Laboratory of Cardiovascular Genetics at the Royal Victoria Hospital.

Condition or disease Intervention/treatment
Dilated Cardiomyopathy (DCM) Other: blood test

Study Design
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Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Family-Based
Time Perspective: Prospective
Study Start Date : January 2008
Estimated Study Completion Date : December 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Cardiomyopathy
U.S. FDA Resources

Groups and Cohorts
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Intervention Details:
    Other: blood test
    looking at DNA

Outcome Measures
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Eligibility Criteria
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients with Dilated cardiomyopathy followed at the Heart Function Clinic and their families
Criteria

Inclusion Criteria:

  • Followed at MUHC Heart Function Centre
  • Documented EF of less than or equal to 35% and an enlarged heart with a left ventricular end-diastolic size of greater than 6 cm.
  • Patient's written consent

Exclusion Criteria:

  • Patients with a known underlying condition that results in a weakened and enlarged heart
  • Patients unable to read and understand the consent form
  • Patients who do not wish to participate
Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00523653


Contacts
Contact: Nadia S Giannetti, MD (514)934 1934 ext 32850 nadia.giannetti@much.mcgill.ca

Locations
Canada, Quebec
Royal Victoria Hospital Recruiting
Montreal, Quebec, Canada, H3A 1A1
Contact: Nadia Giannetti, MD       nadia.giannetti@muhc.mcgill.ca   
Sponsors and Collaborators
McGill University Health Center
Investigators
Principal Investigator: Nadia S Giannetti, MD McGill University Hospital Centre
Principal Investigator: Jamie Engert, PhD McGill University Health Center
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party: Dr Nadia Giannetti, McGill University Health Center
ClinicalTrials.gov Identifier: NCT00523653     History of Changes
Other Study ID Numbers: BMB 07-004
First Posted: August 31, 2007    Key Record Dates
Last Update Posted: March 19, 2008
Last Verified: March 2008

Additional relevant MeSH terms:
Cardiomyopathies
Cardiomyopathy, Dilated
Heart Diseases
Cardiovascular Diseases
Cardiomegaly