Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00523198|
Recruitment Status : Completed
First Posted : August 31, 2007
Last Update Posted : December 4, 2014
The purpose of the study is:
- to correlate salivary cortisol to free serum cortisol (as salivary cortisol is considered to be almost complete free cortisol) and,
- to correlate free serum cortisol to total serum cortisol levels
Both in patients with septic shock (severe sepsis requiring vasopressors).
We believe that:
- total serum cortisol does not correlate with free serum cortisol in patient with septic shock and,
- that salivary cortisol correlates with free serum cortisol and can be used to determine the level of free serum cortisol.
|Condition or disease|
Free serum cortisol is considered the active hormone.
In patients with septic shock only the total serum cortisol level is available, however, the free cortisol level can be normal despite a low total cortisol level due to changes in the serum protein.
The hormone can be replaced improperly in these patients and contribute to poor outcome in septic shock.
We are studying adult MICU patients with septic shock who are not receiving corticosteroid replacement.
This study does not include any intervention.
In-hospital or 28-day mortality are registered in all the patients.
|Study Type :||Observational|
|Actual Enrollment :||60 participants|
|Official Title:||Correlation Between Salivary Cortisol and Free Serum Cortisol Compared to Total Serum Cortisol in MICU Patients With Septic Shock|
|Study Start Date :||February 2007|
|Actual Primary Completion Date :||August 2008|
|Actual Study Completion Date :||October 2008|
- Salivary cortisol [ Time Frame: one year ]salivary cortisol in mg/dL
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00523198
|United States, Texas|
|The University of Texas- Health Science Center at Houston|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Rosa M Estrada-Y-Martin, MD||The University of Texas-Health Science Center at Houston / Division of Pulmonary, Sleep and Critical Care Medicine|