Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock
The purpose of the study is:
- to correlate salivary cortisol to free serum cortisol (as salivary cortisol is considered to be almost complete free cortisol) and,
- to correlate free serum cortisol to total serum cortisol levels
Both in patients with septic shock (severe sepsis requiring vasopressors).
We believe that:
- total serum cortisol does not correlate with free serum cortisol in patient with septic shock and,
- that salivary cortisol correlates with free serum cortisol and can be used to determine the level of free serum cortisol.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Correlation Between Salivary Cortisol and Free Serum Cortisol Compared to Total Serum Cortisol in MICU Patients With Septic Shock|
- Salivary cortisol [ Time Frame: one year ] [ Designated as safety issue: No ]salivary cortisol in mg/dL
|Study Start Date:||February 2007|
|Study Completion Date:||October 2008|
|Primary Completion Date:||August 2008 (Final data collection date for primary outcome measure)|
Free serum cortisol is considered the active hormone.
In patients with septic shock only the total serum cortisol level is available, however, the free cortisol level can be normal despite a low total cortisol level due to changes in the serum protein.
The hormone can be replaced improperly in these patients and contribute to poor outcome in septic shock.
We are studying adult MICU patients with septic shock who are not receiving corticosteroid replacement.
This study does not include any intervention.
In-hospital or 28-day mortality are registered in all the patients.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00523198
|United States, Texas|
|The University of Texas- Health Science Center at Houston|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Rosa M Estrada-Y-Martin, MD||The University of Texas-Health Science Center at Houston / Division of Pulmonary, Sleep and Critical Care Medicine|