Proteomics of Severe Traumatic Brain Injury: A Feasibility Study

The recruitment status of this study is unknown because the information has not been verified recently.

Verified February 2009 by University of Calgary.
Recruitment status was Recruiting

Sponsor:

Collaborator:

Canadian Intensive Care Foundation

Information provided by:

University of Calgary

ClinicalTrials.gov Identifier:

NCT00522496

First received: August 27, 2007

Last updated: February 20, 2009

Last verified: February 2009

History of Changes

Purpose

The purpose of this study is to:

Determine the temporal course of matrix metalloproteinase (MMP) expression in patients wiht severe traumatic brain injury
Determine the temporal course of the expression of MMP-related inflammatory mediators of secondary injury in patients with severe traumatic brain injury
Describe the association of physiological changes and standard microdialysis analyte measures (lactate, pyruvate, lactate/pyruvate ratio, and glucose) to MMP and neuroinflammatory marker concentrations.

Condition
Brain Injuries, Traumatic


Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Proteomics of Severe Traumatic Brain Injury: A Feasibility Study

Resource links provided by NLM:

MedlinePlus related topics: Traumatic Brain Injury

U.S. FDA Resources

Further study details as provided by University of Calgary:


Estimated Enrollment:	8
Study Start Date:	July 2007
Estimated Study Completion Date:	August 2009

Eligibility


Ages Eligible for Study:	18 Years and older (Adult, Senior)
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

All patients referred to Foothills Medical Centre, the regional trauma centre for Southern Alberta

Criteria

Inclusion Criteria:

Patient is 18 years of age or older
Patient has GCS less than 9
Patient requires intracranial pressure monitoring
Patient life expectancy greater than 72 hours

Exclusion Criteria:

Patient's TBI is greater than 24 hours old
Patient is less than 18 years of age
Patient does not require intracranial pressure monitoring
Patient has life expectancy less than 72 hours
Patient has GCS greater or equal to 9
Patient is currently enrolled in another study

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00522496

Contacts


Contact: David A Zygun, MD	403-944-1691	dzygun@ucalgary.ca

Locations


Canada, Alberta
Foothills Medical Centre	Recruiting
Calgary, Alberta, Canada, T2N 2T9
Contact: David A Zygun, MD 403-944-1691 dzygun@ucalgary.ca
Principal Investigator: David A Zygun, MD
Sub-Investigator: John Hurlbert, MD
Sub-Investigator: Ian Parney, MD
Sub-Investigator: Walter Hader, MD
Sub-Investigator: Clare Gallagher, MD
Sub-Investigator: Wee Yong, P.hD
Sub-Investigator: Christopher Doig, MD
Sub-Investigator: Paul Kubes, MD
Sub-Investigator: Andreas Kramer, MD

Sponsors and Collaborators

University of Calgary

Canadian Intensive Care Foundation

Investigators


Principal Investigator:	Zygun A David, MD	University of Calgary

More Information


Responsible Party:	David Zygun Principal Investigator, University of Calgary
ClinicalTrials.gov Identifier:	NCT00522496 History of Changes
Other Study ID Numbers:	20216
Study First Received:	August 27, 2007
Last Updated:	February 20, 2009
Health Authority:	Canada: Ethics Review Committee

Keywords provided by University of Calgary:


Craniocerebral trauma matrix metalloproteinase microdialysis

Additional relevant MeSH terms:


Wounds and Injuries Brain Injuries Brain Diseases Central Nervous System Diseases	Nervous System Diseases Craniocerebral Trauma Trauma, Nervous System

ClinicalTrials.gov processed this record on September 26, 2016

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