This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Prebiotic Fiber as a Modifier of Satiety Hormones and Body Weight in Overweight and Obese Adults

This study has been completed.
Information provided by:
University of Calgary Identifier:
First received: August 27, 2007
Last updated: May 21, 2008
Last verified: May 2008
The purpose of this study is to determine if oligofructose supplementation promotes weight loss in overweight and obese adults.

Condition Intervention
Obesity Dietary Supplement: Oligofructose Dietary Supplement: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effect of Oligofructose Versus Placebo on Body Weight and Satiety Hormone Secretion in Overweight and Obese Adults.

Resource links provided by NLM:

Further study details as provided by University of Calgary:

Primary Outcome Measures:
  • Body weight [ Time Frame: 3 months ]

Secondary Outcome Measures:
  • Plasma satiety hormones [ Time Frame: 3 months ]

Enrollment: 48
Study Start Date: January 2007
Study Completion Date: August 2007
Primary Completion Date: May 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: 1
Dietary Supplement: Oligofructose
21 grams per day in distributed over 3 doses per day for 3 months
Other Name: Raftilose P95
Placebo Comparator: 2
Dietary Supplement: Placebo
7.89 grams of placebo maltodextrin divided into 3 equal doses per day for 3 months
Other Name: Maltrin M100

Detailed Description:
Obesity is a primary health concern for many western countries as it is linked to several chronic diseases as well as, large health care costs. Although obesity is a multifactorial disease, it is known that levels of satiety hormones including glucagon like peptide-1 (GLP-1) and peptide YY (PYY) are reduced in obesity. The ability of prebiotic fiber to promote weight loss through the production of satiety hormones has been tested previously using rodents. Here it was found that prebiotic supplementation resulted in a decreased energy intake, higher GLP-1 levels in the plasma and increased proglucagon mRNA levels in the gut. This study will address the important question of whether prebiotic fiber supplementation is effective in reducing body weight in overweight or obese human subjects.

Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • overweight or class I obese individuals with BMI between 25 kg/m2 and 34.9 kg/m2
  • stable body weight in previous 3 months

Exclusion Criteria:

  • Type 1 and Type 2 diabetes
  • clinically significant cardiovascular abnormalities
  • liver or pancreas disease
  • major gastrointestinal surgeries
  • are pregnant or lactating
  • exhibit alcohol or drug dependence
  • on drugs influencing appetite
  • are following a diet or exercise regime designed for weight loss
  • have a body mass greater than 350lb
  • chronic use of antacids or bulk laxatives
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00522353

Canada, Alberta
Faculty of Kinesiology, Roger Jackson Centre for Health and Wellness Research
Calgary, Alberta, Canada, T2N 1N4
Sponsors and Collaborators
University of Calgary
Principal Investigator: Raylene A. Reimer, PhD, RD University of Calgary
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Raylene Reimer, Associate Professor, University of Calgary Identifier: NCT00522353     History of Changes
Other Study ID Numbers: UC 20085
Study First Received: August 27, 2007
Last Updated: May 21, 2008

Keywords provided by University of Calgary:
weight loss
satiety hormones
body composition
appetite ratings

Additional relevant MeSH terms:
Body Weight
Signs and Symptoms
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs processed this record on June 22, 2017