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Analysis of Genes That Predispose People to Develop High Blood Pressure

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
University of Maryland Identifier:
First received: August 27, 2007
Last updated: March 29, 2017
Last verified: March 2017
High blood pressure affects nearly one third of all individuals in the United States. It is believed that genetic factors may predispose some people to develop this disease. This study will identify and characterize variations in three genes known to play a part in the development of high blood pressure.


Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Genetic and Functional Analyses of Chromosome 1 Hypertension Susceptibility

Further study details as provided by University of Maryland:

Actual Study Start Date: August 2003
Study Completion Date: July 2011
Primary Completion Date: July 2006 (Final data collection date for primary outcome measure)
Detailed Description:
High blood pressure is one of the most common health problems in this country. It can be caused by many factors, including stress, diet, diabetes, kidney disease, or obesity. In many people, there is no identifiable cause for their high blood pressure. If high blood pressure goes untreated, it can lead to heart failure, kidney failure, or stroke. Previous studies have shown that variations in three genes in chromosome 1—ATP1B1, RGS5, and SELE—cause some people to be more susceptible to developing high blood pressure. All three of these genes are involved in the development of proteins that play a role in regulating blood pressure, but it is not known exactly how variations in these genes affect blood pressure levels. This study will examine previously collected genetic samples from participants in two clinical trials, the GenNet study and the Heredity and Phenotype Interaction (HAPI) Heart study. Study researchers will analyze the samples to identify and characterize variations in the ATP1B1, RGS5, and SELE genes. Results from this study may lead to more effective diagnostic and treatment options for people with high blood pressure.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Participants in the GenNet and HAPI Heart studies (genetic samples will be examined)
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Please refer to this study by its identifier: NCT00522119

Sponsors and Collaborators
University of Maryland
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Yen Pei C. Chang, PhD University of Maryland
  More Information

Responsible Party: University of Maryland Identifier: NCT00522119     History of Changes
Other Study ID Numbers: 1403
R01HL088120 ( US NIH Grant/Contract Award Number )
R01HL088120-01A1 ( US NIH Grant/Contract Award Number )
Study First Received: August 27, 2007
Last Updated: March 29, 2017

Keywords provided by University of Maryland:
Essential Hypertension
High Blood Pressure

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases processed this record on April 26, 2017