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Analysis of Genes That Predispose People to Develop High Blood Pressure

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00522119
First Posted: August 29, 2007
Last Update Posted: March 31, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
University of Maryland
  Purpose
High blood pressure affects nearly one third of all individuals in the United States. It is believed that genetic factors may predispose some people to develop this disease. This study will identify and characterize variations in three genes known to play a part in the development of high blood pressure.

Condition
Hypertension

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Genetic and Functional Analyses of Chromosome 1 Hypertension Susceptibility

Further study details as provided by University of Maryland:

Actual Study Start Date: August 2003
Study Completion Date: July 2011
Primary Completion Date: July 2006 (Final data collection date for primary outcome measure)
Detailed Description:
High blood pressure is one of the most common health problems in this country. It can be caused by many factors, including stress, diet, diabetes, kidney disease, or obesity. In many people, there is no identifiable cause for their high blood pressure. If high blood pressure goes untreated, it can lead to heart failure, kidney failure, or stroke. Previous studies have shown that variations in three genes in chromosome 1—ATP1B1, RGS5, and SELE—cause some people to be more susceptible to developing high blood pressure. All three of these genes are involved in the development of proteins that play a role in regulating blood pressure, but it is not known exactly how variations in these genes affect blood pressure levels. This study will examine previously collected genetic samples from participants in two clinical trials, the GenNet study and the Heredity and Phenotype Interaction (HAPI) Heart study. Study researchers will analyze the samples to identify and characterize variations in the ATP1B1, RGS5, and SELE genes. Results from this study may lead to more effective diagnostic and treatment options for people with high blood pressure.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Participants in the GenNet and HAPI Heart studies (genetic samples will be examined)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00522119


Sponsors and Collaborators
University of Maryland
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
Principal Investigator: Yen Pei C. Chang, PhD University of Maryland
  More Information

Responsible Party: University of Maryland
ClinicalTrials.gov Identifier: NCT00522119     History of Changes
Other Study ID Numbers: 1403
R01HL088120 ( U.S. NIH Grant/Contract )
R01HL088120-01A1 ( U.S. NIH Grant/Contract )
First Submitted: August 27, 2007
First Posted: August 29, 2007
Last Update Posted: March 31, 2017
Last Verified: March 2017

Keywords provided by University of Maryland:
Essential Hypertension
High Blood Pressure

Additional relevant MeSH terms:
Hypertension
Vascular Diseases
Cardiovascular Diseases