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Epidemiology of Fluoroquinolone Resistance in Human Commensal Flora in Patients Hospitalised in Medical Wards

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00520715
First Posted: August 24, 2007
Last Update Posted: June 23, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Pr Bruno Fantin
Information provided by (Responsible Party):
Dr Victoire de Lastours, Association Pour le Recherche en Infectiologie et en Médecine Interne
  Purpose
Emergence of bacterial resistance to antibiotics, which is a major public health issue, appears to involve predominantly commensal flora. No data exists concerning risk factors for the carriage of fluoroquinolone resistant bacteria in the flora of hospitalised patients. We will conduct a prospective open study including all unselected patients hospitalised in medical wards of one hospital. Nasal, pharyngeal and rectal swabs will be performed upon admission as well as a review of potential risk factors, after patient's information and acceptance. Resistance testing aiming 3 pathogens (Staphylococcus, Streptococcus and E. coli) will be performed on all specimens, and a case control study will compare risk factors from the resistant and non-resistant groups, for each pathogen. A thousand patients should be included in a year's time. This work could help understand risk factors involved in the carriage of fluoroquinolone resistant pathogens, potentially responsible for invasive infections and inter-patient transmission of resistance. Limiting bacterial resistance and transmission is a goal that can be successfully undertaken only if resistance mechanisms, but also risk factors of acquiring resistant bacteria are better understood.

Condition
Colonization Multi Drug Resistant Bacteria Hospitalized Patients

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Epidemiology and Risk Factors Study of the Carriage of Fluoroquinolone Resistant Bacteria in the Commensal Flora of Patients Hospitalised in Medical Wards

Further study details as provided by Dr Victoire de Lastours, Association Pour le Recherche en Infectiologie et en Médecine Interne:

Enrollment: 640
Study Start Date: June 2007
Study Completion Date: December 2007
Primary Completion Date: November 2007 (Final data collection date for primary outcome measure)
Groups/Cohorts
Patients at hospital admission
Patients at hospital admission in medical wards on our tertiray care hospital (Hôpital Beaujon, Clichy, France).

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
adults patients at hospital admission hospital stay >24 hours informed consent required
Criteria

Inclusion Criteria:

  • all adult patients admitted to the internal medicine, oncology, cardiology and geriatric unit of Beaujon Hospital, Clichy, France.
  • patient agreement

Exclusion Criteria:

  • Age < 18
  • patient refusal or incapable
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00520715


Locations
France
Hôpital Beaujon
Clichy, Ile de France, France, 92110
Sponsors and Collaborators
Association Pour le Recherche en Infectiologie et en Médecine Interne
Pr Bruno Fantin
Investigators
Principal Investigator: Victoire de Lastours, MD
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Dr Victoire de Lastours, MD, Association Pour le Recherche en Infectiologie et en Médecine Interne
ClinicalTrials.gov Identifier: NCT00520715     History of Changes
Other Study ID Numbers: FQ/EPI
First Submitted: July 11, 2007
First Posted: August 24, 2007
Last Update Posted: June 23, 2015
Last Verified: June 2015

Keywords provided by Dr Victoire de Lastours, Association Pour le Recherche en Infectiologie et en Médecine Interne:
fluoroquinolone resistance
commensal flora
carriage

Additional relevant MeSH terms:
Fluoroquinolones
Anti-Bacterial Agents
Anti-Infective Agents
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action