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Clinicopathological and Molecular Correlation of Acrochordon in Relation to Human Papillomavirus Infection

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ClinicalTrials.gov Identifier: NCT00520078
Recruitment Status : Unknown
Verified February 2007 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : August 23, 2007
Last Update Posted : August 23, 2007
Information provided by:

Study Description
Brief Summary:
Acrochordon, or soft fibroma, is a common benign skin tumor which is generally regarded as a sign of cutaneous aging or as a reaction to friction since it occurs in the intertriginous areas. Recent studies have shown the presence of human papillomaviruses, especially the mucosal types, on some of the intertriginous lesions. This study is to analyze the different clinical presentations of acrochordon and correlate them with pathologic and molecular human papillomavirus findings. Further goal is to improve the ability to differentiate acrochordon and its possible prevention and treatment. Also, it may have an implication on the transmission and prevention of cervical carcinoma.

Condition or disease
Acrochordon Skin Tag Soft Fibroma Human Papillomavirus HPV

Detailed Description:

Acrochordon, also called soft fibroma, skin tag or fibroepithelial polyp, is a common cutaneous disorder characterized by a polypoid growth composed of fibroblasts in a loose collagenous stroma, sometimes with proliferation of blood vessels. They appear as soft, skin-colored or light brownish skin tumors. Three types of lesions may occur, (1) multiple small, furrowed papules, especially on the neck and in the axillae, (2) single or multiple filiform smooth growths in various locations, and (3) solitary bag-like pedunculated growth, seen most commonly on the lower trunk. Most regard them as a sign of cutaneous aging.

The presence of human papillomaviruses (HPVs), especially the mucosal types, has been demonstrated in acrochordon. Our previous experience on HPV typing of skin tags also confirms this finding. Though HPV is a ubiquitous virus, the presence of mucosal type HPV in non-mucosal sites is exceptional. This investigation is trying to correlate the clinicopathological and HPV molecular typing of acrochordons. A better understanding of acrochordon and its relation to HPV infection may improve the ability to prevent and treat.

Study Design

Study Type : Observational
Estimated Enrollment : 100 participants
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Clinicopathological and Molecular Correlation of Acrochordon in Relation to Human Papillomavirus Infection
Study Start Date : August 2007
Estimated Study Completion Date : August 2008
Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Adult patients with multiple acrochordon on non-anogenital sites who ask to remove the lesions and have signed consent to surgery will be asked to participate in the study

Exclusion Criteria:

  • No special exclusion criteria
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00520078

Contact: Tsen-Fang Tsai, MD +886-2-23123456 ext 5734 tftsai@yahoo.com

National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Tsen-Fang Tsai, MD    +886-2-23123456 ext 5734    tftsai@yahoo.com   
Principal Investigator: Tsen-Fang Tsai, MD         
Sponsors and Collaborators
National Taiwan University Hospital
National Science Council, Taiwan
National Health Research Institutes, Taiwan
Principal Investigator: Tsen-Fang Tsai, MD National Taiwan University Hospital
More Information

ClinicalTrials.gov Identifier: NCT00520078     History of Changes
Other Study ID Numbers: 200701034R
First Posted: August 23, 2007    Key Record Dates
Last Update Posted: August 23, 2007
Last Verified: February 2007

Additional relevant MeSH terms:
Papillomavirus Infections
DNA Virus Infections
Virus Diseases
Tumor Virus Infections
Neoplasms, Fibrous Tissue
Neoplasms, Connective Tissue
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type