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The Effect of Calcium on Fecal Fat and Energy Excretion

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ClinicalTrials.gov Identifier: NCT00519909
Recruitment Status : Unknown
Verified August 2007 by University of Copenhagen.
Recruitment status was:  Recruiting
First Posted : August 23, 2007
Last Update Posted : August 23, 2007
Sponsor:
Collaborators:
Arla Foods
The Danish Dairy Research Foundation, Denmark
FOOD Graduate School, the Royal Veterinary & Agricultural University, Denmark
Danish Research Agency
Information provided by:
University of Copenhagen

Brief Summary:
The overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.

Condition or disease Intervention/treatment Phase
Obesity Other: Dairy calcium Not Applicable

Detailed Description:

Several reports have found inverse associations between calcium intake and body weight. Few intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. The mechanism is not clear, but one possible explanation is reduced absorption of fat in the gut, due to formation of insoluble calcium fatty acid soaps or binding of bile acids which impairs the formation of micelles.

The aim of this study is to examined if a high calcium intake from dairy products, in diets high or normal in fat content, have an effect on fecal energy and fat excretion, concentrations of substrates involved in energy metabolism and blood pressure.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 15 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Study Start Date : August 2007
Estimated Study Completion Date : February 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Calcium

Arm Intervention/treatment
1
Diet with high content of calcium and high content of fat
Other: Dairy calcium
Diets with different content of calcium and fat

2
Diet with low content of calcium and high content of fat
Other: Dairy calcium
Diets with different content of calcium and fat

3
Diet with high content of calcium and normal content of fat
Other: Dairy calcium
Diets with different content of calcium and fat

4
Diet with low content of calcium and normal content of fat
Other: Dairy calcium
Diets with different content of calcium and fat

5
Diet with high content of calcium fra supplement and high content of fat
Other: Dairy calcium
Diets with different content of calcium and fat




Primary Outcome Measures :
  1. Fecal fat excretion, fecal energy excretion, calcium excretion, cholesterol

Secondary Outcome Measures :
  1. Vitamin D, changes in lipolyse


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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy meals
  • BMI 24-31 kg/m2
  • age between 18-50 years

Exclusion Criteria:

  • donation of blood 6 months before and under the study
  • milk allergy, diabetes, hypertension, hyperlipidemia, cronic infectious disease
  • use of dietary supplements 3 months before and under the study
  • smoking
  • elite athletes
  • use of medication

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00519909


Contacts
Contact: Arne Astrup, Prof. MD +45 3533 2476 ast@life.ku.dk

Locations
Denmark
Dept. of Human Nutrition, Faculty of Life Sciences, University of Copenhagen Recruiting
Frederiksberg, Denmark, 1958
Contact: Arne Astrup, prof. MD    +45 3533 2476    ast@life.ku.dk   
Contact: Janne K Lorenzen, PhD student    +45 3533 3632    jakh@life.ku.dk   
Principal Investigator: Janne K Lorenzen, PhD student         
Sponsors and Collaborators
University of Copenhagen
Arla Foods
The Danish Dairy Research Foundation, Denmark
FOOD Graduate School, the Royal Veterinary & Agricultural University, Denmark
Danish Research Agency
Investigators
Principal Investigator: Janne K Lorenzen, PhD student Dept. of Human Nutrition, Faculty of Life Sciences, Univerity of Copenhagen

ClinicalTrials.gov Identifier: NCT00519909     History of Changes
Other Study ID Numbers: H-KF-01-144/02
First Posted: August 23, 2007    Key Record Dates
Last Update Posted: August 23, 2007
Last Verified: August 2007

Keywords provided by University of Copenhagen:
dairy products, calcium, fat excretion, energy excretion

Additional relevant MeSH terms:
Calcium, Dietary
Bone Density Conservation Agents
Physiological Effects of Drugs