Resistance Exercise Reduces the Expression of Inflammation and Fibrosis Associated Genes in Autoimmune Myositis Patients
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ClinicalTrials.gov Identifier: NCT00519103 |
Recruitment Status
:
Completed
First Posted
: August 21, 2007
Last Update Posted
: August 30, 2007
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Myositis Exercise | Other: exercise | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 8 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Study Start Date : | December 2002 |
Actual Study Completion Date : | March 2003 |

Arm | Intervention/treatment |
---|---|
Experimental: 1
Active resistive excercise for 7 weeks
|
Other: exercise |
- effects of physical exercise muscle strength and function in patients with chronic polymyositis or dermatomyositis [ Time Frame: 7weeks ]
- effects of exercise on gene expression and corresponding protein expression in muscle tissue and on signs of inflammation in peripheral blood [ Time Frame: 7 weeks ]

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Ages Eligible for Study: | 18 Years to 80 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients were included if they had a disease duration more than 12 months and they had to have a stable, low disease activity and medication for three months before enrollment in the study
Exclusion Criteria:
- Patients with inclusion body myositis were excluded as well as patients with co morbidities that contradicted vigorous exercise (severe osteoporosis with multiple fractures, malignant disease severe lung disease) or if they were physically active more than once a week.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00519103
Sweden | |
Rheumatology unit, Karolinska Unirversity hospital | |
Stockholm, Sweden |
Principal Investigator: | Ingrid E Lundberg, MD, PhD | Rheumatology Unit, Department of Medicine, in Solna, Karolinska Institutet |
ClinicalTrials.gov Identifier: | NCT00519103 History of Changes |
Other Study ID Numbers: |
Lundberg-1 |
First Posted: | August 21, 2007 Key Record Dates |
Last Update Posted: | August 30, 2007 |
Last Verified: | August 2007 |
Keywords provided by Karolinska Institutet:
microarray Inflammtion fibrosis |
Additional relevant MeSH terms:
Myositis Muscular Diseases Musculoskeletal Diseases Neuromuscular Diseases Nervous System Diseases |