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Organ Protection With Sevoflurane Postconditioning

This study has been completed.
Information provided by:
University of Zurich Identifier:
First received: August 20, 2007
Last updated: July 18, 2011
Last verified: July 2011
Organ protection, volatile anesthetics, postconditioning, hepatic surgery

Condition Intervention
Hepatectomy Drug: Sevoflurane

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Role of Volatile Anesthetics for Hepatic Protection in Ischemia-reperfusion: Postconditioning

Resource links provided by NLM:

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • Liver transaminase AST [ Time Frame: Postoperative phase until discharge ]
    Peak value

Secondary Outcome Measures:
  • ALT peak value [ Time Frame: Postoperative phase until discharge ]
  • Course of transaminases [ Time Frame: From the day before surgery, to 6 hours after surgery, up to postoperative day 7 ]
  • Postoperative complications [ Time Frame: Postoperative phase until discharge ]
  • Length of hospital stay [ Time Frame: Postoperative phase until discharge ]
  • Need for prolonged intensive care unit stay (>24 hours) [ Time Frame: Postoperative phase until discharge ]

Enrollment: 125
Study Start Date: January 2008
Study Completion Date: September 2010
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Sevoflurane
Sevoflurane for pharmacological postconditioning
Drug: Sevoflurane
3.2 Vol % for postconditioning
Experimental: Propofol
Anesthesia maintenance with propofol instead of Sevoflurane postconditioning
Drug: Sevoflurane
3.2 Vol % for postconditioning

Detailed Description:
This study aims at the evaluation of a potential attenuation of ischemic-reperfusion injury in the liver with sevoflurane postconditioning upon reperfusion.

Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion criteria:

  • older than 18 years
  • patients undergoing liver resection (benign or malignant tumors)

Exclusion criteria:

  • non-german speakers
  • laparoscopic liver resection
  • coagulopathy (platelets < 50'000/ml, Quick < 50%)
  • liver cirrhosis
  Contacts and Locations
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Please refer to this study by its identifier: NCT00518908

University Hospital of Zurich
Zurich, Switzerland
Sponsors and Collaborators
University of Zurich
Study Director: 01 Studienregister MasterAdmins UniversitaetsSpital Zuerich
  More Information

Responsible Party: BECK SCHIMMER Beatrice, Professor, University Hospital Zurich, Department of Anesthesiology Identifier: NCT00518908     History of Changes
Other Study ID Numbers: StV 34-2007
Study First Received: August 20, 2007
Last Updated: July 18, 2011

Keywords provided by University of Zurich:
Ischemia reperfusion injury
Organ protection

Additional relevant MeSH terms:
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General
Central Nervous System Depressants
Physiological Effects of Drugs processed this record on August 18, 2017