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Risk Factors for Quinolone Resistance Among ESBL Producing Klebsiella Species

This study is ongoing, but not recruiting participants.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00518661
First Posted: August 21, 2007
Last Update Posted: June 9, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Yohei Doi, University of Pittsburgh
  Purpose
This is a retrospective chart review. This proposed study aims to document the risk factors for quinolone resistance in bloodstream isolates of Klebsiella species. Additionally, the adequacy of empiric antibiotic therapy for Klebsiella bloodstream infections will be assessed.

Condition
Quinolone Resistance ESBL Klebsiella Species Infection

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Risk Factors for Quinolone Resistance Among Extended-Spectrum Beta-Lactamase-Producing Klebsiella Species

Resource links provided by NLM:


Further study details as provided by Yohei Doi, University of Pittsburgh:

Estimated Enrollment: 500
Study Start Date: August 2007
Estimated Study Completion Date: December 2025
Estimated Primary Completion Date: December 2025 (Final data collection date for primary outcome measure)
Detailed Description:
This is a retrospective chart review. This proposed study aims to document the risk factors for quinolone resistance in bloodstream isolates of Klebsiella species. Additionally, the adequacy of empiric antibiotic therapy for Klebsiella bloodstream infections will be assessed. This research is (c) important because identification of risk factors may allow earlier initiation of appropriate therapy in patients infected with these bacteria. Additionally, we will identify whether horizontal spread is responsible for this increasing trend.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
quinolone resistant
Criteria

Inclusion Criteria:

  • must be quinolone resistant among ESBL producing klebsiella species

Exclusion Criteria:

  • Those not meeting entry criteria
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00518661


Locations
United States, Pennsylvania
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
University of Pittsburgh
Investigators
Principal Investigator: Brian Potoski, PharmD University of Pittsburgh
  More Information

Responsible Party: Yohei Doi, Associate Professor, University of Pittsburgh
ClinicalTrials.gov Identifier: NCT00518661     History of Changes
Other Study ID Numbers: PRO07070356
investigator funding ( Other Identifier: UPMC )
First Submitted: August 17, 2007
First Posted: August 21, 2007
Last Update Posted: June 9, 2017
Last Verified: June 2017

Keywords provided by Yohei Doi, University of Pittsburgh:
quinolone resistance
ESBL
Klebsiella species
Infection

Additional relevant MeSH terms:
Klebsiella Infections
Enterobacteriaceae Infections
Gram-Negative Bacterial Infections
Bacterial Infections