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Neuroimaging Studies of Depression in Parkinson's Disease

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ClinicalTrials.gov Identifier: NCT00518258
Recruitment Status : Completed
First Posted : August 20, 2007
Last Update Posted : May 17, 2013
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this study is to investigate similarities and differences in the neural pathways of depressed Parkinson's patients, non-depressed Parkinson's patients, and healthy controls using magnetic resonance imaging (MRI) of the brain and neuropsychological assessment.

Condition or disease
Parkinson's Disease

Detailed Description:
Depression is a common and potentially serious complication of Parkinson's disease (PD). Studies show that approximately 40 percent of PD patients are depressed. There is evidence that these patients have deficits in neuropsychological function relative to non-depressed PD patients. Despite the widespread toll on emotional health posed by PD, few studies have undertaken a comprehensive examination of the neural underpinnings of Parkinsonian depression. In this project, we will compare depressed versus non-depressed Parkinson patients to a sample of demographically-matched healthy controls using neuropsychological assessment and magnetic resonance imaging (MRI). To investigate possible effects of anti-Parkinsonian medication on mood, cognitive function, and neural response, PD patients will be tested both off and on Parkinsonian medications.

Study Design

Study Type : Observational
Estimated Enrollment : 120 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Neuroimaging Studies of Depression in Parkinson's Disease
Study Start Date : July 2006
Primary Completion Date : December 2011
Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts

Patient Group
Control Group

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Neurology clinics, community sample

Inclusion Criteria:

  • right-handed
  • willing/able to undergo magnetic resonance imaging (MRI)

Exclusion Criteria:

  • history of neurological condition other than Parkinson's disease
  • history of psychiatric condition other than depression
  • history of substance abuse/dependence
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00518258

United States, Kentucky
University of Kentucky
Lexington, Kentucky, United States, 40536
Sponsors and Collaborators
Lee Blonder
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
Principal Investigator: Lee X. Blonder, PhD University of Kentucky
More Information

Responsible Party: Lee Blonder, PI, University of Kentucky
ClinicalTrials.gov Identifier: NCT00518258     History of Changes
Other Study ID Numbers: R01-MH78228-2
First Posted: August 20, 2007    Key Record Dates
Last Update Posted: May 17, 2013
Last Verified: April 2013

Keywords provided by Lee Blonder, University of Kentucky:
Parkinson's Disease
Magnetic Resonance Imaging (MRI)
neuropsychological assessment

Additional relevant MeSH terms:
Parkinson Disease
Behavioral Symptoms
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases