Neuroimaging Studies of Depression in Parkinson's Disease
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ClinicalTrials.gov Identifier: NCT00518258
Recruitment Status :
First Posted : August 20, 2007
Last Update Posted : May 17, 2013
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
The purpose of this study is to investigate similarities and differences in the neural pathways of depressed Parkinson's patients, non-depressed Parkinson's patients, and healthy controls using magnetic resonance imaging (MRI) of the brain and neuropsychological assessment.
Condition or disease
Depression is a common and potentially serious complication of Parkinson's disease (PD). Studies show that approximately 40 percent of PD patients are depressed. There is evidence that these patients have deficits in neuropsychological function relative to non-depressed PD patients. Despite the widespread toll on emotional health posed by PD, few studies have undertaken a comprehensive examination of the neural underpinnings of Parkinsonian depression. In this project, we will compare depressed versus non-depressed Parkinson patients to a sample of demographically-matched healthy controls using neuropsychological assessment and magnetic resonance imaging (MRI). To investigate possible effects of anti-Parkinsonian medication on mood, cognitive function, and neural response, PD patients will be tested both off and on Parkinsonian medications.
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Ages Eligible for Study:
40 Years to 85 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Neurology clinics, community sample
willing/able to undergo magnetic resonance imaging (MRI)
history of neurological condition other than Parkinson's disease
history of psychiatric condition other than depression