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Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure (CARNEBI)

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ClinicalTrials.gov Identifier: NCT00517725
Recruitment Status : Completed
First Posted : August 17, 2007
Last Update Posted : September 16, 2010
Sponsor:
Information provided by:
Centro Cardiologico Monzino

Brief Summary:

The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity.

Both could influence exercise capacity in normoxic as well as hypoxic conditions.


Condition or disease Intervention/treatment Phase
Chronic Heart Failure Drug: carvedilol Drug: bisoprolol Drug: Nebivolol Phase 4

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Investigator)
Primary Purpose: Treatment
Official Title: Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure: Effects on Exercise Capacity and Hypoxia, Chemoreceptor Response, Pulmonary Function
Study Start Date : July 2007
Actual Study Completion Date : May 2010


Arm Intervention/treatment
Active Comparator: Carvedilol Drug: carvedilol
Active Comparator: Bisoprolol Drug: bisoprolol
Active Comparator: Nebivolol Drug: Nebivolol



Primary Outcome Measures :
  1. exercise capacity [ Time Frame: two months ]

Secondary Outcome Measures :
  1. lung diffusion [ Time Frame: two months ]


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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Chronic heart failure patients in stable clinical condition

Exclusion Criteria:

  • No comorbidity
  • NYHA class IV

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00517725


Locations
Italy
Centro Cardiologico Monzino, University of Milan
Milan, Italy, 20138
Sponsors and Collaborators
Centro Cardiologico Monzino
Investigators
Principal Investigator: Piergiuseppe Agostoni, MD, PhD Centro Cardiologico Monzino
Study Chair: Giancarlo Marenzi, MD Centro Cardiologico Monzino

Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Piergiuseppe Agostoni, Centro Cardiologico Monzino - Univeristy of Milan
ClinicalTrials.gov Identifier: NCT00517725     History of Changes
Other Study ID Numbers: R76-CCM S78/407
First Posted: August 17, 2007    Key Record Dates
Last Update Posted: September 16, 2010
Last Verified: September 2010

Keywords provided by Centro Cardiologico Monzino:
exercise
lung diffusion
hypoxia
chemoreceptor
beta-blockers
heart failure

Additional relevant MeSH terms:
Heart Failure
Heart Diseases
Cardiovascular Diseases
Carvedilol
Bisoprolol
Nebivolol
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Antihypertensive Agents
Vasodilator Agents
Adrenergic alpha-1 Receptor Antagonists
Adrenergic alpha-Antagonists
Adrenergic beta-1 Receptor Agonists
Adrenergic beta-Agonists
Adrenergic Agonists
Sympatholytics
Autonomic Agents
Peripheral Nervous System Agents
Adrenergic beta-1 Receptor Antagonists