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Source Profiling of Biohazardous Aerosols in Hospitals

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ClinicalTrials.gov Identifier: NCT00517660
Recruitment Status : Completed
First Posted : August 17, 2007
Last Update Posted : August 22, 2013
Sponsor:
Collaborator:
Hong Kong University of Science and Technology
Information provided by:
Hospital Authority, Hong Kong

Brief Summary:
To characterise the physical parameters (number concentration, size distribution and their trajectories) of aerosols (droplets) generated in high risk procedures.

Condition or disease
Respiratory Tract Infections

Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Source Profiling of Biohazardous Aerosols in Hospitals
Study Start Date : March 2006
Actual Study Completion Date : June 2006

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Sampling Method:   Non-Probability Sample
Study Population
60 from each groups. Healthy subjects - recruited from voluntary basis. LRTI - recruited from patient wards with consent. URTI - recruited from out-patient clinic with consent.
Criteria

Inclusion Criteria:

  1. Adult patients (>18 years old) that can give valid consent
  2. URTI: with symptoms such as coryza, sore throat, nasal discharge, cough and sputum +/- fever. Amongst these, cough should be a major complaint.
  3. LRTI (CAP): acute lower respiratory illness of no other known cause which is usually associated with fever, symptoms and signs of the chest and abnormalities on the CXR. (BTS 1993).

Exclusion Criteria:

  1. Pneumonia developed at or after 48 hours, or history of hospital admissions within 1 month of the present admission (to exclude hospital-acquired infections)
  2. Patients who are unable to cooperate with the study protocols (such as mentally confused, dementia) or are physically unable to sit or stand independently to carry out the tests optimally.
  3. Patients with TOCC associations with infections such Avian Flu or SARS (travel to endemic areas, at-risk occupations, close contacts with index cases, especially with compatible clinical features) or NPA revealed positivity of influenza A/B
  4. Patients who are clinically or haemodynamically unstable, such as the need for inotropes, oxygen supplement of >2L/min, any types of shock, etc.
  5. Underlying diseases that might affect the coughing effort (such as musculoskeletal diseases, or severe kyphoscoliosis)

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00517660


Locations
China
Queen Elizabeth Hospital
Hong Kong, China
Sponsors and Collaborators
Hospital Authority, Hong Kong
Hong Kong University of Science and Technology
Investigators
Principal Investigator: Ming Fang, Prof Institute for the Environment, The Hong Kong University of Science and Technology

Additional Information:
ClinicalTrials.gov Identifier: NCT00517660     History of Changes
Other Study ID Numbers: KC/KE-04-0071/ER-1
HARECCTR0500055
First Posted: August 17, 2007    Key Record Dates
Last Update Posted: August 22, 2013
Last Verified: August 2013

Keywords provided by Hospital Authority, Hong Kong:
Healthy subjects
Lower Respiratory Tract Infections
Upper Respiratory Tract Infections

Additional relevant MeSH terms:
Infection
Respiratory Tract Infections
Respiratory Tract Diseases